Purification, amino-acid sequence and partial characterization of two toxins with anti-insect activity from the venom of the South American scorpion Tityus bahiensis (Buthidae).

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorPimenta, Adriano Monteiro de Castro-
Autor(es): dc.creatorEauclaire, Marie France Martin-
Autor(es): dc.creatorRochat, Hervé-
Autor(es): dc.creatorFigueiredo, Suely Gomes de-
Autor(es): dc.creatorKalapothakis, Evanguedes-
Autor(es): dc.creatorAfonso, Luís Carlos Crocco-
Autor(es): dc.creatorLima, Maria Elena de-
Data de aceite: dc.date.accessioned2019-11-06T13:32:31Z-
Data de disponibilização: dc.date.available2019-11-06T13:32:31Z-
Data de envio: dc.date.issued2015-03-12-
Data de envio: dc.date.issued2015-03-12-
Data de envio: dc.date.issued2001-
Fonte completa do material: dc.identifierhttp://www.repositorio.ufop.br/handle/123456789/4617-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/557628-
Descrição: dc.descriptionWe report here the isolation by a two-step chromatographic procedure of two new toxins from the South American scorpion Tityus bahiensis. Their amino-acid sequences and some of their biological features were established. The two toxins have different biological properties. Toxin TbIT-I had almost no activity or pharmacological effects in vertebrate tissues whereas it was lethal to house ¯ies (LD50 80.0 ng/house ¯y). In contrast, Tb2-II was active against both mammals (intracerebroventricular injection of 100 ng/mouse was lethal) and insects (LD50 40.0 ng/house ¯y). The amino-acid sequences of these toxins were established and found to be similar (60±95%) to previously described b-toxins from the Tityus genus. Based on the available comparative information, this study attempts identify possible structure±function relationships that may be responsible for the differences in bioactivity displayed by these toxins.-
Idioma: dc.languageen-
Direitos: dc.rightsO Periódico Toxicon concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3530901439097.-
Palavras-chave: dc.subjectTityus bahiensis-
Palavras-chave: dc.subjectToxin-
Palavras-chave: dc.subjectAnti-insect activity-
Palavras-chave: dc.subjectThree-dimensional models-
Título: dc.titlePurification, amino-acid sequence and partial characterization of two toxins with anti-insect activity from the venom of the South American scorpion Tityus bahiensis (Buthidae).-
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