Retromer-containing tubules leaving early endosomes [4e. Honorable Mention]

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMardones, Gonzalo A.-
Data de aceite: dc.date.accessioned2019-08-21T18:24:28Z-
Data de disponibilização: dc.date.available2019-08-21T18:24:28Z-
Data de envio: dc.date.issued2016-10-26-
Data de envio: dc.date.issued2016-10-26-
Fonte completa do material: dc.identifierhttp://acervodigital.unesp.br/handle/unesp/364990-
Fonte completa do material: dc.identifierhttp://objetoseducacionais2.mec.gov.br/handle/mec/10768-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/471196-
Descrição: dc.descriptionPresentes the retromer is a multisubunit complex that mediates retrograde transport of the cation-independent mannose 6-phosphate receptor (CI-MPR) from endosomes to the trans-Golgi network (TGN). The CI-MPR binds newly-synthesized acid hydrolases at the TGN and carries them within clathrin-coated vesicles to endosomes, where the hydrolases are released for eventual transport to lysosomes. The retromer then functions to retrieve the unoccupied receptors to the TGN, where they engage in further cycles of acid hydrolase sorting. The mammalian retromer comprises two biogenetically distinct subcomplexes of tightly assembled subunits: a homodimer or heterodimer of SNX1 or SNX2 and a heterotrimer composed of Vps26, Vps29 and Vps35. This video shows a HeLa cell transiently expressing Vps29-GFP. By means of high-speed live-cell imaging the video shows the association of Vps29-GFP to both early endosomes and highly mobile vesicles. It also shows the retromer in tubular elements detaching from early endosomes-
Descrição: dc.descriptionComponente Curricular::Educação Superior::Ciências Biológicas::Morfologia-
Publicador: dc.publisherThe American Society for Cell Biology, ASBC Image & Video Library-
Relação: dc.relation259.mov-
Direitos: dc.rightsYou may use the Images only for research and educational purposes in an educational institution. Images may be stored on a network server, hard drive or removable media, but only while this Agreement remains in effect. All of the Images you use must be accompanied by a notice stating, "© [Date and Author's or Owner's Name]. All rights reserved. Reprinted under license from The American Society for Cell Biology." The notice shall appear with the Images or on a credits page. "Educational purposes" means (i) non-commercial instruction or curriculum based teaching by educators to students at nonprofit educational institutions, (ii) planned non-commercial study, investigation or research directed toward making a contribution to a field of knowledge, or (iii) presentation of research findings at non-commercial peer conferences, workshops or seminars, but in any event there must be express written permission from ASCB before an Image can be published. "Educational institutions" include K-12 schools, colleges and universities. Libraries, museums, hospitals, research institutes and other nonprofit organizations are considered educational institutions when they engage in nonprofit instructional, research or scholarly activities for educational purposes-
Palavras-chave: dc.subjectCell-
Palavras-chave: dc.subjectRetrograde transport-
Palavras-chave: dc.subjectRetromer-
Palavras-chave: dc.subjectEducação Superior::Ciências Biológicas::Morfologia::Citologia e Biologia Celular-
Título: dc.titleRetromer-containing tubules leaving early endosomes [4e. Honorable Mention]-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Acervo Digital Unesp

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