Theoretical foundations and future perspectives for new evaluations and clinical interventions in individuals with copd with sarcopenia : the interaction between gerontology and pulmonology

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorProbst, Vanessa Suziane [Orientador]-
Autor(es): dc.contributorCamillo, Carlos Augusto Marçal-
Autor(es): dc.contributorMañas, Leocadio Rodríguez-
Autor(es): dc.contributorTeixeira, Denilson de Castro-
Autor(es): dc.contributorOkamura, Larissa Araújo de Castro-
Autor(es): dc.creatorLoyola, Walter Aquiles Sepúlveda-
Data de aceite: dc.date.accessioned2025-05-15T13:00:50Z-
Data de disponibilização: dc.date.available2025-05-15T13:00:50Z-
Data de envio: dc.date.issued2024-05-01-
Data de envio: dc.date.issued2024-05-01-
Data de envio: dc.date.issued2025-05-15-
Data de envio: dc.date.issued2025-05-15-
Fonte completa do material: dc.identifierhttps://repositorio.uel.br/handle/123456789/8795-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/978709-
Descrição: dc.descriptionTese (Doutorado em Ciências da Reabilitação) - Universidade Estadual de Londrina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências da Reabilitação-
Descrição: dc.descriptionAbstract: Introduction: The following doctoral thesis aimed to answer the main gaps in the literature related to the relationship between COPD and sarcopenia, its clinical impact and associated biological factors Additionally, we have described and defined a new geriatric syndrome and proposed a new exercise program based on functional tasks in order to prevent and treat the functional impact caused by sarcopenia and other geriatric syndromes Methods: Seven studies were included in this thesis, developed in collaboration with different international research centers In the first study the clinical impact, prevalence and criteria to diagnose sarcopenia in individuals with COPD was investigated In the second study the main biological mechanisms associated with the prevalence of sarcopenia in individuals with COPD were investigated The third and fourth studies analysed the relationship between oxidative stress and some clinical variables related to the presence of sarcopenia in individuals with COPD In the fifth study the criteria and clinical impact of a new geriatric syndrome called osteosarcopenia were presented The sixth and seventh studies proposed a new exercise intervention method to treat older adults with geriatric syndromes Results: The first study reported that overall sarcopenia prevalence varied from 15% to 34%, being greater in people with more severe condition [37% (95%CI 248–54)] In addition, the presence of sarcopenia has a negative impact upon important clinical outcomes The second study found that oxidative stress, chronic inflammation, genetic and metabolic factors are the main biological mechanism related to the presence of sarcopenia in individuals with COPD The third and fourth studies reported that the total radical trapping antioxidant parameter (TRAP) and advanced oxidation protein products (AOPP) are important biomarkers related to clinical variables associated to sarcopenia in individuals with COPD and that antioxidant capacity was correlated with muscle mass and strength in this population (r from 5 to 64) The fifth study reported that osteosarcopenia (using the severe sarcopenia classification) conferred an increased rate of falls [odds ratios (ORs) from 283 to 363; P <5 for all] and fractures (ORs from 386 to 438; P < 5 for all) The sixth and seventh studies found that the exercise intervention method improves the clinical variables of sarcopenia in community older adults Conclusion: Sarcopenia is highly prevalent in individuals with COPD, generating a negative impact on various clinical variables Its origin is due to the presence of various factors such as oxidative stress and systemic inflammation related to COPD Sarcopenia may also be associated with low bone mineral mass, a syndrome called osteosarcopenia, which has a greater impact than sarcopenia alone Functional physical exercise could be a great intervention to reduce the risk of sarcopenia and other geriatric syndromes Since this exercise method has been studied in community older adults, future clinical randomized control trials are needed in individuals with COPD and other comorbidities-
Formato: dc.formatapplication/pdf-
Idioma: dc.languagept_BR-
Relação: dc.relationDoutorado-
Relação: dc.relationCiências da Reabilitação-
Relação: dc.relationCentro de Ciências da Saúde-
Relação: dc.relationPrograma de Pós-Graduação em Ciências da Reabilitação-
Palavras-chave: dc.subjectGeriatria-
Palavras-chave: dc.subjectIdosos-
Palavras-chave: dc.subjectDoenças-
Palavras-chave: dc.subjectPneumologia - Idoso-
Palavras-chave: dc.subjectTratamento-
Palavras-chave: dc.subjectGeriatrics-
Palavras-chave: dc.subjectElderly - Diseases-
Palavras-chave: dc.subjectPulmonology - Rehabilitation - Treatment-
Título: dc.titleTheoretical foundations and future perspectives for new evaluations and clinical interventions in individuals with copd with sarcopenia : the interaction between gerontology and pulmonology-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional da UEL - RIUEL

Não existem arquivos associados a este item.