Biological properties of a novel multifunctional host defense peptide from the skin secretion of the chaco tree frog, Boana raniceps

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Brasília, Institute of Biology, Department of Physiological Sciences, Laboratory of Toxinology-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistry-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biology, Department of Physiological Sciences, Laboratory of Toxinology-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biology, Department of Physiological Sciences, Laboratory of Toxinology-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistry-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biology, Department of Physiological Sciences, Laboratory of Toxinology-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistry-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Gene Biology-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Gene Biology-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistry-
Autor(es): dc.contributorUniversity of São Paulo, Institute of Biomedical Sciences, Department of Microbiology-
Autor(es): dc.contributorUniversity of São Paulo, Institute of Biomedical Sciences, Department of Microbiology-
Autor(es): dc.contributorUniversity of São Paulo, Institute of Biomedical Sciences, Department of Microbiology-
Autor(es): dc.contributorUniversity of São Paulo, Institute of Biomedical Sciences, Department of Microbiology-
Autor(es): dc.contributorUniversity of São Paulo, Institute of Biomedical Sciences, Department of Microbiology-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Biophysics-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Biophysics-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistry-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biology, Department of Physiological Sciences, Laboratory of Toxinology-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistry-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biology, Department of Physiological Sciences, Laboratory of Toxinology-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistry-
Autor(es): dc.creatorSantana, Carlos José Correia-
Autor(es): dc.creatorMagalhães, Ana Carolina Martins-
Autor(es): dc.creatorPrías Márquez, César Augusto-
Autor(es): dc.creatorFalico, Diego Alejandro-
Autor(es): dc.creatorSantos Júnior, Agenor de Castro Moreira dos-
Autor(es): dc.creatorLima, Beatriz Dolabela-
Autor(es): dc.creatorRicart, Carlos André Ornelas-
Autor(es): dc.creatorPilger, Denise Regina Bairros de-
Autor(es): dc.creatorBonotto, Rafaela Milan-
Autor(es): dc.creatorMoraes, Carolina Borsoi-
Autor(es): dc.creatorFreitas Júnior, Lúcio Holanda de-
Autor(es): dc.creatorMorales Álvares, Alice da Cunha-
Autor(es): dc.creatorFreitas, Sônia Maria-
Autor(es): dc.creatorLuz, Isabelle Souza-
Autor(es): dc.creatorPires Júnior, Osmindo Rodrigues-
Autor(es): dc.creatorFontes, Wagner-
Autor(es): dc.creatorCastro, Mariana de Souza-
Data de aceite: dc.date.accessioned2025-03-18T18:59:10Z-
Data de disponibilização: dc.date.available2025-03-18T18:59:10Z-
Data de envio: dc.date.issued2025-01-09-
Data de envio: dc.date.issued2025-01-09-
Data de envio: dc.date.issued2020-05-20-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/51306-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/biom10050790-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-9781-3670-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-0689-2770-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-8722-5103-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-9875-9407-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-5140-8573-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/959726-
Descrição: dc.descriptionIn recent years, the number of new antimicrobial drugs launched on the market has decreased considerably even though there has been an increase in the number of resistant microbial strains. Thus, antimicrobial resistance has become a serious public health problem. Amphibian skin secretions are a rich source of host defense peptides, which generally are cationic and hydrophobic molecules, with a broad-spectrum of activity. In this study, one novel multifunctional defense peptide was isolated from the skin secretion of the Chaco tree frog, Boana raniceps. Figainin 2 (1FLGAILKIGHALAKTVLPMVTNAFKPKQ28) is cationic and hydrophobic, adopts an α-helical structure in 50% (v/v) trifluoroethanol (TFE), and is thermally stable. This peptide exhibited activity against Gram-negative and Gram-positive pathogenic bacteria arboviruses, T. cruzi epimastigotes; however, it did not show activity against yeasts. Figainin 2 also showed antiproliferative activity on cancer cells, is moderately active on human erythrocytes, and activates the oxidative burst in human neutrophils.-
Descrição: dc.descriptionInstituto de Ciências Biológicas (IB)-
Descrição: dc.descriptionDepartamento de Ciências Fisiológicas (IB CFS)-
Descrição: dc.descriptionDepartamento de Biologia Celular (IB CEL)-
Descrição: dc.descriptionPrograma de Pós-Graduação em Biologia Animal-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherMDPI-
Direitos: dc.rightsAcesso Aberto-
Palavras-chave: dc.subjectAnfíbio-
Palavras-chave: dc.subjectSecreção cutânea-
Palavras-chave: dc.subjectPeptídeos-
Palavras-chave: dc.subjectPeptídeos antimicrobianos-
Palavras-chave: dc.subjectNeutrófilos-
Título: dc.titleBiological properties of a novel multifunctional host defense peptide from the skin secretion of the chaco tree frog, Boana raniceps-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB - Rep. 1

Não existem arquivos associados a este item.