microRNA signatures in prodromal REM sleep behavior disorder and early Parkinson's disease as noninvasive biomarkers

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Autor(es): dc.contributorUniversity of Brasília, Faculty of Agronomy and Veterinary Medicine, Central Institute of Sciences, Technology for Gene Therapy Laboratory-
Autor(es): dc.contributorNetwork for Translational Neuroscience, International Consortium for Academic Cooperation in Experimental and Clinical Studies Regarding Neurodegenerative Diseases, Brazil-
Autor(es): dc.contributorUniversity of Brasília, Faculty of Agronomy and Veterinary Medicine, Central Institute of Sciences, Technology for Gene Therapy Laboratory-
Autor(es): dc.contributorNetwork for Translational Neuroscience, International Consortium for Academic Cooperation in Experimental and Clinical Studies Regarding Neurodegenerative Diseases, Brazil-
Autor(es): dc.contributorUniversity of Brasília, Faculty of Agronomy and Veterinary Medicine, Central Institute of Sciences, Technology for Gene Therapy Laboratory-
Autor(es): dc.contributorNetwork for Translational Neuroscience, International Consortium for Academic Cooperation in Experimental and Clinical Studies Regarding Neurodegenerative Diseases, Brazil-
Autor(es): dc.contributorInstitute of Psychiatry of Brasília, Brasília, DF, Brazil-
Autor(es): dc.contributorUniversity of Brasília, Faculty of Agronomy and Veterinary Medicine, Central Institute of Sciences, Technology for Gene Therapy Laboratory-
Autor(es): dc.contributorNetwork for Translational Neuroscience, International Consortium for Academic Cooperation in Experimental and Clinical Studies Regarding Neurodegenerative Diseases, Brazil-
Autor(es): dc.contributorUniversity of Brasília, Laboratory of Neuroscience and Behavior-
Autor(es): dc.contributorNeurology Clinic, Medical Department, Chamber of Deputies, The National Congress, Brasília, DF, Brazil-
Autor(es): dc.contributorPhilipps University Marburg, Department of Neurology, Marburg, Germany-
Autor(es): dc.contributorMinnesota Regional Sleep Disorders Center, Departments of Psychiatry, Hennepin County Medical Center and University of Minnesota Medical School-
Autor(es): dc.contributorUniversity of Brasília, Faculty of Agronomy and Veterinary Medicine, Central Institute of Sciences, Technology for Gene Therapy Laboratory-
Autor(es): dc.contributorNetwork for Translational Neuroscience, International Consortium for Academic Cooperation in Experimental and Clinical Studies Regarding Neurodegenerative Diseases, Brazil-
Autor(es): dc.contributorUniversity of Brasília, Faculty of Medicine, Department of Neurology and Sleep Medicine-
Autor(es): dc.creatorAlmeida, Ricardo Titze de-
Autor(es): dc.creatorAlmeida, Simoneide Souza Titze de-
Autor(es): dc.creatorFerreira, Gabriel Ginani-
Autor(es): dc.creatorSilva, Andrezza Paula Brito-
Autor(es): dc.creatorBrandão, Pedro Renato de Paula-
Autor(es): dc.creatorOertel, Wolfgang H.-
Autor(es): dc.creatorSchenck, Carlos H.-
Autor(es): dc.creatorRodrigues, Raimundo Nonato Delgado-
Data de aceite: dc.date.accessioned2025-03-18T18:42:44Z-
Data de disponibilização: dc.date.available2025-03-18T18:42:44Z-
Data de envio: dc.date.issued2024-11-24-
Data de envio: dc.date.issued2024-11-24-
Data de envio: dc.date.issued2020-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/51008-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.sleep.2020.12.012-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-5019-4742-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-8024-7403-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/954715-
Descrição: dc.descriptionThe flow of gene expression or “The central dogma of molecular biology”: DNA e RNA e protein, pro- posed by Watson & Crick sixty years ago, is a tightly controlled cell process. In the middle of this journey, the mRNA molecule is regulated by “RNA interference” (RNAi), a posttranscriptional gene silencing mechanism. A microRNA is an endogenous short double-stranded RNA that down-regulates hundreds of mRNAs by RNAi, maintaining healthy cell physiology. In contrast, aberrant expressions of microRNAs play a role in Parkinson's disease (PD) pathogenesis. The damage may start at an early period of brain degeneration, in the non-motor or “prodromal” stage, where autonomic, mood and sleep changes are often manifested. REM-sleep behavior disorder (RBD) is the prodromal manifestation with the highest odds for conversion into PD, thereby a valuable phenotype for disease prediction. The present review focuses on microRNAs' role in the pathogenesis of PD and RBD, summarizing the state-of-the-art of these RNA molecules as noninvasive biomarkers for non-motor prodromal (RBD) and early PD.-
Descrição: dc.descriptionFaculdade de Agronomia e Medicina Veterinária (FAV)-
Descrição: dc.descriptionFaculdade de Medicina (FM)-
Descrição: dc.descriptionPrograma de Pós-Graduação em Ciências da Saúde-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B. V.-
Relação: dc.relationhttps://www.sciencedirect.com/science/article/pii/S1389945720305621?via%3Dihub-
Direitos: dc.rightsAcesso Restrito-
Palavras-chave: dc.subjectMicroRNA-
Palavras-chave: dc.subjectParkinson, Doença de-
Palavras-chave: dc.subjectSono REM-
Palavras-chave: dc.subjectBiomarcadores-
Título: dc.titlemicroRNA signatures in prodromal REM sleep behavior disorder and early Parkinson's disease as noninvasive biomarkers-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB - Rep. 1

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