Selective Ru(II)/benzoate complexes against triple-negative breast tumor cells and their interactions with DNA and BSA

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributormailto:tamarateixeira@estudante.ufscar.br-
Autor(es): dc.contributorChemistry Department, ICEB, Federal University of Ouro Preto – UFOP-
Autor(es): dc.contributorEmbrapa-
Autor(es): dc.contributorChemistry Department, ICEB, Federal University of Ouro Preto – UFOP-
Autor(es): dc.contributorPhysics Institute of São Carlos, University of São Paulo – USP-
Autor(es): dc.contributorUniversidade de Brasília-
Autor(es): dc.contributorhttps://orcid.org/0000-0003-2783-0816-
Autor(es): dc.creatorTeixeira, Tamara-
Autor(es): dc.creatorRibeiro, Gabriel H.-
Autor(es): dc.creatorGonçalves, Guilherme R.-
Autor(es): dc.creatorAraújo Neto, João Honorato de-
Autor(es): dc.creatorOliveira, Katia Mara de-
Autor(es): dc.creatorCorrea, Rodrigo S.-
Data de aceite: dc.date.accessioned2025-03-18T18:10:01Z-
Data de disponibilização: dc.date.available2025-03-18T18:10:01Z-
Data de envio: dc.date.issued2025-03-13-
Data de envio: dc.date.issued2025-03-13-
Data de envio: dc.date.issued2024-04-22-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/51884-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.ica.2024.122078-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-1127-6083-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-4749-0281-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/943278-
Descrição: dc.descriptionNew ruthenium(II) complexes bearing benzoate (AB) ligand with the general formula [Ru(AB)(bipy)(P–P)]PF6, where 2,2′-bipyridine (bipy) and different diphosphine ligands, (P–P) = 1,2′-bis(diphenylphosphine)ethane(dppe, 1), 1,3′-bis(diphenylphosphine)propane (dppp, 2) and 1,2′-bis(diphenylphosphine)ferrocene (dppf, 3), were synthesized. The compounds were characterized by molar conductivity, elemental analysis, cyclic voltammetry, infrared and UV–Vis spectroscopies, NMR, and by single-crystal X-ray diffraction for complexes 1 and 2. The complexes showed a weak interaction to CT-DNA through DNA minor groove, with Kb values at around 103-104 M− 1. CT-DNA interaction assays by viscosity and circular dichroism (CD) suggested that the compounds do not significantly alter the secondary DNA structure. The complexes are cytotoxic against MDA-MB-231, MCF7 (breast) and A549 (lung) tumor cell lines, with IC50 values in the range of 1 to 17 µM. The compounds 1-3 showed high selectivity against triple-negative breast tumor cells. Remarkably, complexes 1 and 3 show greater cytotoxic activity against cells than cisplatin, being promising agents for tumor treatment.-
Descrição: dc.descriptionInstituto de Química-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier-
Relação: dc.relationhttps://www.sciencedirect.com/science/article/pii/S0020169324001683?via%3Dihub-
Direitos: dc.rightsAcesso Restrito-
Direitos: dc.rights© 2024 Elsevier B.V. All rights reserved.-
Palavras-chave: dc.subjectRutênio-
Palavras-chave: dc.subjectElementos químicos - atividade citotóxica-
Palavras-chave: dc.subjectMamas - câncer - tratamento-
Título: dc.titleSelective Ru(II)/benzoate complexes against triple-negative breast tumor cells and their interactions with DNA and BSA-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB - Rep. 1

Não existem arquivos associados a este item.