Therapeutic effects of Zymomonas mobilis on experimental DSS-Induced colitis mouse model

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Autor(es): dc.contributorUniversity of Brasilia, Institute of Biological Sciences, Department of Cell Biology-
Autor(es): dc.contributorUniversity of Brasilia, Medicine Faculty, Molecular Pathology Graduation Program-
Autor(es): dc.contributorUniversity of Brasilia, Institute of Biological Sciences, Department of Cell Biology-
Autor(es): dc.contributorUniversity of Brasilia, Institute of Biological Sciences, Department of Cell Biology-
Autor(es): dc.contributorUniversity of Brasilia, Institute of Biological Sciences, Molecular Biology Graduation Program-
Autor(es): dc.contributorUniversity of Brasilia, Institute of Biological Sciences, Department of Cell Biology-
Autor(es): dc.contributorUniversity of Brasilia, Institute of Biological Sciences, Molecular Biology Graduation Program-
Autor(es): dc.contributorUniversity of Brasilia, Institute of Biological Sciences-
Autor(es): dc.contributorUniversity of Brasilia, Veterinary Pathology Laboratory-
Autor(es): dc.contributorUniversity of Brasilia, Veterinary Pathology Laboratory-
Autor(es): dc.contributorEmbrapa Agroenergy, Laboratory of Genetics and Molecular Biology-
Autor(es): dc.contributorUniversity of Brasilia, Institute of Biological Sciences, Department of Cell Biology-
Autor(es): dc.contributorNational Institute of Science and Technology (iii-INCT), Institute for Immunology Investigation-
Autor(es): dc.contributorUniversity of Brasilia, Institute of Biological Sciences, Department of Cell Biology-
Autor(es): dc.contributorNational Institute of Science and Technology (iii-INCT), Institute for Immunology Investigation-
Autor(es): dc.creatorAlmo, Manuela Maragno do-
Autor(es): dc.creatorSousa, Isabel Garcia-
Autor(es): dc.creatorOlinto, Vitor Guimarães-
Autor(es): dc.creatorPinhate, Sylvia Barbosa-
Autor(es): dc.creatorJivago, José Luiz de Paula Rôlo-
Autor(es): dc.creatorSousa, Davi Emanuel Ribeiro de-
Autor(es): dc.creatorCastro, Márcio Botelho de-
Autor(es): dc.creatorRubini, Marciano Régis-
Autor(es): dc.creatorMaranhão, Andrea Queiroz-
Autor(es): dc.creatorBrigido, Marcelo Macedo-
Data de aceite: dc.date.accessioned2025-03-18T18:03:43Z-
Data de disponibilização: dc.date.available2025-03-18T18:03:43Z-
Data de envio: dc.date.issued2024-10-21-
Data de envio: dc.date.issued2024-10-21-
Data de envio: dc.date.issued2023-11-16-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/50649-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/microorganisms11112793-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-0361-7730-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-6326-9803-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-1237-0693-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-3996-0856-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-1946-7191-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-7136-7059-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/941148-
Descrição: dc.descriptionZymomonas mobilis, a Gram-negative bacteria observed in some popular beverages, is considered safe and has been studied for its potential therapeutic benefits. In this study, we explored its effects on the inflammatory process, tissue integrity, differential gene expression, and microbiota composition in an experimental dextran sulfate sodium (DSS)-induced colitis model in mice. As a result, Z. mobilis alleviated the symptoms caused by DSS administration, as indicated by reduced weight loss, disease activity index, a significant reduction in the colon weight/length ratio, and histopathological improvement. Also, Z. mobilis could restore the mucosal barrier as well as increase the expression of Muc3 and Ocln genes. An analysis of 16S rRNA sequences showed that Z. mobilis alters gut microbiota, increasing Akkermansia muciniphila abundance and decreasing Escherichia coli. Furthermore, Z. mobilis seems to be involved in potentiating a regulatory phenotype by inducing immunomodulatory genes like Tgfb, Il5, Il10, and Foxp3 and reducing the relative mRNA expression of proinflammatory cytokines TNF, Il6, and Il17. Our data suggest that Z. mobilis could alleviate disease progression and be considered a possible probiotic adjuvant for pathologies of the bowel.-
Descrição: dc.descriptionInstituto de Ciências Biológicas (IB)-
Descrição: dc.descriptionDepartamento de Biologia Celular (IB CEL)-
Descrição: dc.descriptionFaculdade de Medicina (FM)-
Descrição: dc.descriptionFaculdade de Agronomia e Medicina Veterinária (FAV)-
Descrição: dc.descriptionPrograma de Pós-Graduação em Patologia Molecular-
Descrição: dc.descriptionPrograma de Pós-Graduação em Biologia Molecular-
Descrição: dc.descriptionPrograma de Pós-Graduação em Ciências Animais-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherMDPI-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rights© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)-
Palavras-chave: dc.subjectBactérias-
Palavras-chave: dc.subjectColite-
Palavras-chave: dc.subjectMicrobiota-
Palavras-chave: dc.subjectImunomodulação-
Palavras-chave: dc.subjectProbióticos-
Título: dc.titleTherapeutic effects of Zymomonas mobilis on experimental DSS-Induced colitis mouse model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB - Rep. 1

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