Increased prevalence of unstable HLA-C variants in HIV-1 rapid-progressor patients

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Autor(es): dc.contributorUniversity of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics-
Autor(es): dc.contributorUniversity of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics-
Autor(es): dc.contributorUniversity of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics-
Autor(es): dc.contributorUniversity of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics-
Autor(es): dc.contributorUniversity of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics-
Autor(es): dc.contributorUniversity of Brasília, Faculty of Health Science, Lab of Molecular NeuroVirology-
Autor(es): dc.contributorUniversity of São Paulo, Faculdade de Medicina FMUSP, Medical Investigation Laboratory Unit 56 (LIM/56)-
Autor(es): dc.contributorUniversity of São Paulo, Faculdade de Medicina FMUSP, Medical Investigation Laboratory Unit 56 (LIM/56)-
Autor(es): dc.contributorUniversity of São Paulo, Institute of Tropical Medicine, Faculty of Medicine-
Autor(es): dc.contributorUniversity of Brasília, Faculty of Health Science, Lab of Molecular NeuroVirology-
Autor(es): dc.contributorUniversity of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics-
Autor(es): dc.contributorUniversity of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics-
Autor(es): dc.creatorStefani, Chiara-
Autor(es): dc.creatorSangalli, Antonella-
Autor(es): dc.creatorLocatelli, Elena-
Autor(es): dc.creatorFederico, Tania-
Autor(es): dc.creatorMalerba, Giovanni-
Autor(es): dc.creatorRomanelli, Maria Grazia-
Autor(es): dc.creatorArgañaraz, Gustavo Adolfo-
Autor(es): dc.creatorSilva, Bosco Christiano Maciel da-
Autor(es): dc.creatorSilva, Alberto Jose Duarte da-
Autor(es): dc.creatorCasseb, Jorge-
Autor(es): dc.creatorArgañaraz, Enrique Roberto-
Autor(es): dc.creatorRuggiero, Alessandra-
Autor(es): dc.creatorZipeto, Donato-
Data de aceite: dc.date.accessioned2025-03-18T17:14:09Z-
Data de disponibilização: dc.date.available2025-03-18T17:14:09Z-
Data de envio: dc.date.issued2025-02-25-
Data de envio: dc.date.issued2025-02-25-
Data de envio: dc.date.issued2022-11-26-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/51722-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/ijms232314852-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-8705-8560-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-7360-1195-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-3883-7178-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-4553-2559-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-4359-7594-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-2168-4144-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/924345-
Descrição: dc.descriptionHIV-1 infection in the absence of treatment results in progression toward AIDS. Host genetic factors play a role in HIV-1 pathogenesis, but complete knowledge is not yet available. Since less-expressed HLA-C variants are associated with poor HIV-1 control and unstable HLA-C variants are associated with higher HIV-1 infectivity, we investigated whether there was a correlation between the different stages of HIV-1 progression and the presence of specific HLA-C allotypes. HLA-C genotyping was performed using allele-specific PCR by analyzing a treatment-naïve cohort of 96 HIV-1-infected patients from multicentric cohorts in the USA, Canada, and Brazil. HIV-1-positive subjects were classified according to their different disease progression status as progressors (Ps, n = 48), long-term non-progressors (LTNPs, n = 37), and elite controllers (ECs, n = 11). HLA-C variants were classified as stable or unstable according to their binding stability to β2-microglobulin/peptide complex. Our results showed a significant correlation between rapid progression to AIDS and the presence of two or one unstable HLA-C variants (p-value: 0.0078, p-value: 0.0143, respectively). These findings strongly suggest a link between unstable HLA-C variants both at genotype and at allele levels and rapid progression to AIDS. This work provides further insights into the impact of host genetic factors on AIDS progression.-
Descrição: dc.descriptionFaculdade de Ciências da Saúde (FS)-
Descrição: dc.descriptionDepartamento de Farmácia (FS FAR)-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherMDPI-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).-
Palavras-chave: dc.subjectAIDS (Doença)-
Palavras-chave: dc.subjectHIV-1-
Palavras-chave: dc.subjectAntígenos-
Título: dc.titleIncreased prevalence of unstable HLA-C variants in HIV-1 rapid-progressor patients-
Tipo de arquivo: dc.typelivro digital-
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