Direct and abscopal antitumor responses elicited by AlPcNE-mediated photodynamic therapy in a Murine melanoma model

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Autor(es): dc.contributorUniversity of Brasilia, Faculty of Ceilandia, Laboratory of Nanoscience and Immunology-
Autor(es): dc.contributorUniversity of Brasilia, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Gene Regulation and Mutagenesis-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Gene Regulation and Mutagenesis-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Gene Regulation and Mutagenesis-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Sciences, Laboratory of Applied Immunology-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Sciences, Laboratory of Applied Immunology-
Autor(es): dc.contributorUniversity of Brasilia, Institute of Physics, Laboratory for Softwares and Physics Instrumentation Development-
Autor(es): dc.contributorUniversity of Brasilia, Institute of Physics, Laboratory for Softwares and Physics Instrumentation Development-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Microscopy and Microanalysis-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Microscopy and Microanalysis-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Microscopy and Microanalysis-
Autor(es): dc.contributorUniversity of Brasilia, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Nanoscience and Nanobiotechnology-
Autor(es): dc.contributorUniversity of Brasilia, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Nanoscience and Nanobiotechnology-
Autor(es): dc.contributorUniversity of Brasilia, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Nanoscience and Nanobiotechnology-
Autor(es): dc.contributorUniversity of Brasilia, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Nanoscience and Nanobiotechnology-
Autor(es): dc.contributorUniversity of Brasilia, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Gene Regulation and Mutagenesis-
Autor(es): dc.creatorMorais, José Athayde Vasconcelos-
Autor(es): dc.creatorBarros, Pedro Henrique Aragão-
Autor(es): dc.creatorBrígido, Marcelo de Macedo-
Autor(es): dc.creatorMarina, Clara Luna-
Autor(es): dc.creatorBocca, Anamélia Lorenzetti-
Autor(es): dc.creatorMariano, André de Lima e Silva-
Autor(es): dc.creatorSouza, Paulo Eduardo Narcizo de-
Autor(es): dc.creatorPaiva, Karen Letycia Rodrigues de-
Autor(es): dc.creatorSimões, Marina Mesquita-
Autor(es): dc.creatorBáo, Sonia Nair-
Autor(es): dc.creatorCamargo, Luana Cristina-
Autor(es): dc.creatorLongo, João Paulo Figueiró-
Autor(es): dc.creatorMorais, Amanda Alencar Cabral-
Autor(es): dc.creatorAzevedo, Ricardo Bentes de-
Autor(es): dc.creatorFonseca, Marcio José Poças-
Autor(es): dc.creatorMuehlmann, Luis Alexandre-
Data de aceite: dc.date.accessioned2025-03-17T23:11:18Z-
Data de disponibilização: dc.date.available2025-03-17T23:11:18Z-
Data de envio: dc.date.issued2025-02-20-
Data de envio: dc.date.issued2025-02-20-
Data de envio: dc.date.issued2024-09-06-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/51697-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/pharmaceutics16091177-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-3067-4842-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-7136-7059-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-0819-0756-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-3323-5300-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-8013-8250-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-4289-8678-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-2098-4401-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-9814-5827-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-9873-3098-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-7223-037X-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-5154-7263-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-6974-0889-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-2137-9588-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-4711-7583-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/922635-
Descrição: dc.descriptionMelanoma, the most aggressive form of skin cancer, presents a major clinical challenge due to its tendency to metastasize and recalcitrance to traditional therapies. Despite advances in surgery, chemotherapy, and radiotherapy, the outlook for advanced melanoma remains bleak, reinforcing the urgent need for more effective treatments. Photodynamic therapy (PDT) has emerged as a promising alternative, leading to targeted tumor destruction with minimal harm to surrounding tissues. In this study, the direct and abscopal antitumor effects of PDT in a bilateral murine melanoma model were evaluated. Although only one of the two tumors was treated, effects were observed in both. Our findings revealed significant changes in systemic inflammation and alterations in CD4+ and CD8+ T cell populations in treated groups, as evidenced by blood analyses and flow cytometry. High-throughput RNA sequencing (RNA-Seq) further unveiled shifts in gene expression profiles in both treated and untreated tumors. This research sheds light on the novel antitumor and abscopal effects of nanoemulsion of aluminum chloride phthalocyanine (AlPcNE)-mediated PDT in melanoma, highlighting the potential of different PDT protocols to modulate immune responses and to achieve more effective and targeted cancer treatments-
Descrição: dc.descriptionFaculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB Ceilândia-
Descrição: dc.descriptionInstituto de Ciências Biológicas (IB)-
Descrição: dc.descriptionDepartamento de Genética e Morfologia (IB GEM)-
Descrição: dc.descriptionDepartamento de Biologia Celular (IB CEL)-
Descrição: dc.descriptionInstituto de Física (IF)-
Descrição: dc.descriptionPrograma de Pós-Graduação em Biologia Animal-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherMDPI-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).-
Palavras-chave: dc.subjectSistema imunológico-
Palavras-chave: dc.subjectImunoterapia-
Palavras-chave: dc.subjectNanoemulsão-
Palavras-chave: dc.subjectMelanoma-
Título: dc.titleDirect and abscopal antitumor responses elicited by AlPcNE-mediated photodynamic therapy in a Murine melanoma model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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