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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Britto, Constança | - |
Autor(es): dc.creator | Silveira, Celeste Aída Nogueira | - |
Autor(es): dc.creator | Cardoso, Maria Angelica | - |
Autor(es): dc.creator | Marques, Patricia | - |
Autor(es): dc.creator | Ostermayer, Alejandro Luquetti | - |
Autor(es): dc.creator | Macêdo, Vanize de Oliveira | - |
Autor(es): dc.creator | Fernandes, Octavio | - |
Data de aceite: dc.date.accessioned | 2024-10-23T16:46:43Z | - |
Data de disponibilização: dc.date.available | 2024-10-23T16:46:43Z | - |
Data de envio: dc.date.issued | 2017-12-07 | - |
Data de envio: dc.date.issued | 2017-12-07 | - |
Data de envio: dc.date.issued | 2001-08 | - |
Fonte completa do material: dc.identifier | http://repositorio.unb.br/handle/10482/25702 | - |
Fonte completa do material: dc.identifier | https://dx.doi.org/10.1590/S0074-02762001000600014 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/917062 | - |
Descrição: dc.description | Polymerase chain reaction (PCR) was compared with xenodiagnosis performed 20 years after trypanocidal chemotherapy to investigate parasite clearance. Eighty-five seropositive individuals for Chagas disease presenting a positive xenodiagnosis were treated with specific drugs; 37 in the acute phase and 48 in the chronic phase. Fifteen chronic assymptomatic patients received a placebo. Treatment in the acute phase led to PCR negative results in 73% of the cases, while xenodiagnosis was negative in 86%. In the chronic phase, PCR was negative in 65% of the patients and 83% led to xenodiagnosis negative results. Regarding the untreated group (placebo), 73% gave negative results by xenodiagnosis, of which 36% were positive by PCR. Individuals that were considered seronegative (n=10), presented unequivocally negative results in the PCR demonstrating the elimination of parasite DNA. Seventeen individuals had their antibodies titers decreased to such a level that the final results were considered as doubtful and 16 of them presented negative PCR. The molecular method represents a clear advantage over conventional techniques to demonstrate persistent infections in Chagas disease patients that underwent chemotherapy. | - |
Descrição: dc.description | Faculdade de Medicina (FMD) | - |
Formato: dc.format | application/pdf | - |
Idioma: dc.language | en | - |
Publicador: dc.publisher | Instituto Oswaldo Cruz, Ministério da Saúde | - |
Direitos: dc.rights | Acesso Aberto | - |
Direitos: dc.rights | Memórias do Instituto Oswaldo Cruz - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (CC BY NC 4.0). Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000600014&lng=en&tlng=en. Acesso em: 19 mar. 2021. | - |
Palavras-chave: dc.subject | Trypanosoma cruzi | - |
Palavras-chave: dc.subject | DNA de cinetoplasto | - |
Palavras-chave: dc.subject | Chagas, Doença de | - |
Palavras-chave: dc.subject | PCR | - |
Palavras-chave: dc.subject | Tratamento | - |
Título: dc.title | Parasite persistence in treated chagasic patients revealed by xenodiagnosis and polymerase chain reaction | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional – UNB |
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