Parasite persistence in treated chagasic patients revealed by xenodiagnosis and polymerase chain reaction

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorBritto, Constança-
Autor(es): dc.creatorSilveira, Celeste Aída Nogueira-
Autor(es): dc.creatorCardoso, Maria Angelica-
Autor(es): dc.creatorMarques, Patricia-
Autor(es): dc.creatorOstermayer, Alejandro Luquetti-
Autor(es): dc.creatorMacêdo, Vanize de Oliveira-
Autor(es): dc.creatorFernandes, Octavio-
Data de aceite: dc.date.accessioned2024-10-23T16:46:43Z-
Data de disponibilização: dc.date.available2024-10-23T16:46:43Z-
Data de envio: dc.date.issued2017-12-07-
Data de envio: dc.date.issued2017-12-07-
Data de envio: dc.date.issued2001-08-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/25702-
Fonte completa do material: dc.identifierhttps://dx.doi.org/10.1590/S0074-02762001000600014-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/917062-
Descrição: dc.descriptionPolymerase chain reaction (PCR) was compared with xenodiagnosis performed 20 years after trypanocidal chemotherapy to investigate parasite clearance. Eighty-five seropositive individuals for Chagas disease presenting a positive xenodiagnosis were treated with specific drugs; 37 in the acute phase and 48 in the chronic phase. Fifteen chronic assymptomatic patients received a placebo. Treatment in the acute phase led to PCR negative results in 73% of the cases, while xenodiagnosis was negative in 86%. In the chronic phase, PCR was negative in 65% of the patients and 83% led to xenodiagnosis negative results. Regarding the untreated group (placebo), 73% gave negative results by xenodiagnosis, of which 36% were positive by PCR. Individuals that were considered seronegative (n=10), presented unequivocally negative results in the PCR demonstrating the elimination of parasite DNA. Seventeen individuals had their antibodies titers decreased to such a level that the final results were considered as doubtful and 16 of them presented negative PCR. The molecular method represents a clear advantage over conventional techniques to demonstrate persistent infections in Chagas disease patients that underwent chemotherapy.-
Descrição: dc.descriptionFaculdade de Medicina (FMD)-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsMemórias do Instituto Oswaldo Cruz - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (CC BY NC 4.0). Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000600014&lng=en&tlng=en. Acesso em: 19 mar. 2021.-
Palavras-chave: dc.subjectTrypanosoma cruzi-
Palavras-chave: dc.subjectDNA de cinetoplasto-
Palavras-chave: dc.subjectChagas, Doença de-
Palavras-chave: dc.subjectPCR-
Palavras-chave: dc.subjectTratamento-
Título: dc.titleParasite persistence in treated chagasic patients revealed by xenodiagnosis and polymerase chain reaction-
Tipo de arquivo: dc.typelivro digital-
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