A wor1-like transcription factor is essential for virulence of Cryptococcus neoformans

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Autor(es): dc.contributorUniversity of Brasília Medical School, Clinical Medicine Division-
Autor(es): dc.contributorMilitary College-
Autor(es): dc.contributorUniversity of Brasília, Ceilândia College-
Autor(es): dc.contributorUniversity of Brasília, Ceilândia College-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Sciences, Department of Cell Biology-
Autor(es): dc.contributorUniversity of Brasília Medical School, Pathology Division-
Autor(es): dc.contributorPaulista University, Department of Biomedicine-
Autor(es): dc.contributorSão Paulo Federal University, Biological Sciences Department, Cellular and Molecular Biology Division-
Autor(es): dc.contributorDuke University, School of Medicine, Department of Medicine-
Autor(es): dc.contributorCatholic University of Brasília, Graduate School in Genomic Sciences-
Autor(es): dc.creatorPaes, Hugo Costa-
Autor(es): dc.creatorDerengowski, Lorena da Silveira-
Autor(es): dc.creatorPeconick, Luisa Defranco Ferreira-
Autor(es): dc.creatorAlbuquerque, Patrícia-
Autor(es): dc.creatorPappas Júnior, Georgios Joannis-
Autor(es): dc.creatorNicola, André Moraes-
Autor(es): dc.creatorSilva, Fabiana Brandão Alves-
Autor(es): dc.creatorVallim, Marcelo Afonso-
Autor(es): dc.creatorAlspaugh, J. Andrew-
Autor(es): dc.creatorFelipe, Maria Sueli Soares-
Autor(es): dc.creatorFernandes, Larissa-
Data de aceite: dc.date.accessioned2024-10-23T16:35:48Z-
Data de disponibilização: dc.date.available2024-10-23T16:35:48Z-
Data de envio: dc.date.issued2023-10-04-
Data de envio: dc.date.issued2023-10-04-
Data de envio: dc.date.issued2018-11-13-
Fonte completa do material: dc.identifierhttp://repositorio2.unb.br/jspui/handle/10482/46610-
Fonte completa do material: dc.identifierhttps://doi.org/10.3389/fcimb.2018.00369-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/912404-
Descrição: dc.descriptionGti1/Pac2 transcription factors occur exclusively in fungi and their roles vary according to species, including regulating morphological transition and virulence, mating and secondary metabolism. Many of these functions are important for fungal pathogenesis. We therefore hypothesized that one of the two proteins of this family in Cryptococcus neoformans, a major pathogen of humans, would also control virulence-associated cellular processes. Elimination of this protein in C. neoformans results in reduced polysaccharide capsule expression and defective cytokinesis and growth at 37◦C. The mutant loses virulence in a mouse model of cryptococcal infection and retains only partial virulence in the Galleria mellonella alternative model at 30◦C. We performed RNA-Seq experiments on the mutant and found abolished transcription of genes that, in combination, are known to account for all the observed phenotypes. The protein has been named Required for cytokinesis and virulence 1 (Rcv1).-
Descrição: dc.descriptionFaculdade de Medicina (FMD)-
Descrição: dc.descriptionFaculdade UnB Ceilândia (FCE)-
Descrição: dc.descriptionInstituto de Ciências Biológicas (IB)-
Descrição: dc.descriptionFaculdade de Ciências da Saúde (FS)-
Descrição: dc.descriptionDepartamento de Farmácia (FS FAR)-
Descrição: dc.descriptionDepartamento de Biologia Celular (IB CEL)-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherFrontiers-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsCopyright © 2018 Paes, Derengowski, Peconick, Albuquerque, Pappas, Nicola, Silva, Vallim, Alspaugh, Felipe and Fernandes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.-
Palavras-chave: dc.subjectCryptococcus neoformans-
Palavras-chave: dc.subjectCitocinese-
Palavras-chave: dc.subjectVirulência-
Título: dc.titleA wor1-like transcription factor is essential for virulence of Cryptococcus neoformans-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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