Fish oil nanoemulsion supplementation attenuates bleomycin-induced pulmonary fibrosis BALB/c Mice

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Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Science, Nanobiotechnology Laboratory, Genetics & Morphology Department-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Science, Nanobiotechnology Laboratory, Genetics & Morphology Department-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Science, Applied Immunology Laboratory, Cell Biology Department-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Science, Nanobiotechnology Laboratory, Genetics & Morphology Department-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Science, Applied Immunology Laboratory, Cell Biology Department-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Science, Nanobiotechnology Laboratory, Genetics & Morphology Department-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Science, Nanobiotechnology Laboratory, Genetics & Morphology Department-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Science, Applied Immunology Laboratory, Cell Biology Department-
Autor(es): dc.contributorUniversity of Brasília, Faculty of Medicine, Respiratory Physiology Laboratory-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Science, Nanobiotechnology Laboratory, Genetics & Morphology Department-
Autor(es): dc.creatorSouza, Danielle Galdino de-
Autor(es): dc.creatorSantos, Débora Silva-
Autor(es): dc.creatorSimon, Karina Smidt-
Autor(es): dc.creatorMorais, José Athayde Vasconcelos-
Autor(es): dc.creatorCoelho, Luísa Coutinho-
Autor(es): dc.creatorPacheco, Thyago José Arruda-
Autor(es): dc.creatorAzevedo, Ricardo Bentes-
Autor(es): dc.creatorBocca, Anamélia Lorenzetti-
Autor(es): dc.creatorMelo-Silva, César Augusto-
Autor(es): dc.creatorLongo, João Paulo Figueiró-
Data de aceite: dc.date.accessioned2024-10-23T16:34:10Z-
Data de disponibilização: dc.date.available2024-10-23T16:34:10Z-
Data de envio: dc.date.issued2023-07-10-
Data de envio: dc.date.issued2023-07-10-
Data de envio: dc.date.issued2021-
Fonte completa do material: dc.identifierhttp://repositorio2.unb.br/jspui/handle/10482/46042-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/nano12101683-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-3432-0769-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-2395-7748-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-8090-0644-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-2137-9588-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-3323-5300-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-3544-6999-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/911692-
Descrição: dc.descriptionDiets rich in omega-3 or -6 fatty acids will produce different profiles for cell membranes phospholipid constitutions. Omegas 3 and 6 are part of the diet and can modulate the inflammatory profile. We evaluated the effects of the oral absorption of fish oil, when associated with a lipid nanoemulsion in an experimental pulmonary inflammatory model. Pulmonary fibrosis is a disease associated with excessive extracellular matrix deposition. We determined to investigate the morphophysiological mechanisms in mice that were pretreated after induction with bleomycin (BLM). The pretreatment was for 21 days with saline solution, sunflower oil (SO), fish oil (FO), and fish oil nanoemulsion (NEW3). The animals received a daily dose of 50 mg/Kg of docosahexaenoic acid DHA and 10 mg/Kg eicosapentaenoic (EPA) (100 mg/Kg), represented by a daily dose of 40 µL of NEW3. The blank group was treated with the same amount daily (40 µL) during the 21 days of pretreatment. The animals were treated with SO and FO, 100 mg/Kg (containing 58 mg/Kg of polyunsaturated fats/higher% linoleic acid) and 100 mg/Kg (50 mg/Kg of DHA and 10 mg/Kg EPA), respectively. A single dose of 5 mg/mL (50 µL) bleomycin sulfate, by the intratracheal surgical method in BALB/cAnNTac (BALB/c). NEW3 significantly reduced fibrotic progression, which can be evidenced by the protection from loss of body mass, increase in respiratory incursions per minute, decreased spacing of alveolar septa, decreased severity of fibrosis, and changes in the respiratory system. NEW3 attenuated the inflammatory changes developed in the experimental model of pulmonary fibrosis, while group SO showed a significant increase in inflammatory changes. This concluded that the presented results demonstrated that is possible to positively modulate the immune and inflamamtory response to an external agressor, by changing the nutitional intake of specific fatty acids, such as omega-3 placed in fish oil. Moreover, these benefits can be improved by the nanoencapsulation of fish oil in lipid nanoemulsions.-
Descrição: dc.descriptionInstituto de Ciências Biológicas (IB)-
Descrição: dc.descriptionDepartamento de Genética e Morfologia (IB GEM)-
Descrição: dc.descriptionDepartamento de Biologia Celular (IB CEL)-
Descrição: dc.descriptionFaculdade de Medicina (FMD)-
Descrição: dc.descriptionPrograma de Pós-Graduação em Nanociência e Nanobiotecnologia-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherMDPI-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).-
Palavras-chave: dc.subjectNanoemulsão-
Palavras-chave: dc.subjectFibrose pulmonar-
Palavras-chave: dc.subjectMedicamentos-
Palavras-chave: dc.subjectÓleos de peixe-
Título: dc.titleFish oil nanoemulsion supplementation attenuates bleomycin-induced pulmonary fibrosis BALB/c Mice-
Tipo de arquivo: dc.typelivro digital-
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