Altered structural connectivity in olfactory disfunction after mild COVID‑19 using probabilistic tractography

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Autor(es): dc.contributorUniversity of Brasilia, Brasilia University Hospital, Diagnostic Imaging Unit-
Autor(es): dc.contributorUniversity of Brasilia, Faculty of Medicine-
Autor(es): dc.contributorUniversity of Brasilia, Neuroscience and Behavior Lab-
Autor(es): dc.contributorHospital Sírio-Libanês, Brasília-
Autor(es): dc.contributorBrazilian Institute of Neuropsychology and Cognitive Sciences, Advanced Psychometry Laboratory-
Autor(es): dc.contributorHospital Santa Marta, Department of Radiology, Taguatinga-
Autor(es): dc.contributorHospital Santa Marta, Department of Radiology, Taguatinga-
Autor(es): dc.contributorHospital Santa Marta, Department of Radiology, Taguatinga-
Autor(es): dc.contributorUniversity of Brasilia, Faculty of Medicine-
Autor(es): dc.contributorHospital Sírio-Libanês, Brasília-
Autor(es): dc.contributorInstituto de Infectologia Emílio Ribas, Department of Neurology-
Autor(es): dc.contributorUniversity of Brasilia, Faculty of Medicine-
Autor(es): dc.contributorUniversity of Sherbrooke, Sherbrooke Connectivity Imaging Lab, Sherbrooke, QC, Canada-
Autor(es): dc.contributorUniversity of Brasilia, Faculty of Medicine-
Autor(es): dc.creatorBispo, Diógenes Diego de Carvalho-
Autor(es): dc.creatorBrandão, Pedro Renato de Paula-
Autor(es): dc.creatorPereira, Danilo Assis-
Autor(es): dc.creatorMaluf, Fernando Bisinoto-
Autor(es): dc.creatorDias, Bruna Arrais-
Autor(es): dc.creatorParanhos, Hugo Rafael-
Autor(es): dc.creatorGlehn, Felipe von-
Autor(es): dc.creatorOliveira, Augusto César Penalva de-
Autor(es): dc.creatorSoares, Alexandre Anderson de Sousa Munhoz-
Autor(es): dc.creatorDescoteaux, Maxime-
Autor(es): dc.creatorRegattieri, Neysa Aparecida Tinoco-
Data de aceite: dc.date.accessioned2024-10-23T16:27:38Z-
Data de disponibilização: dc.date.available2024-10-23T16:27:38Z-
Data de envio: dc.date.issued2024-09-20-
Data de envio: dc.date.issued2024-09-20-
Data de envio: dc.date.issued2022-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/50397-
Fonte completa do material: dc.identifierhttps://doi.org/10.1038/s41598-023-40115-7-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/909038-
Descrição: dc.descriptionWe aimed to investigate changes in olfactory bulb volume and brain network in the white matter (WM) in patients with persistent olfactory disfunction (OD) following COVID‑19. A cross‑sectional study evaluated 38 participants with OD after mild COVID‑19 and 24 controls, including Sniffin’ Sticks identification test (SS‑16), MoCA, and brain magnetic resonance imaging. Network‑Based Statistics (NBS) and graph theoretical analysis were used to explore the WM. The COVID‑19 group had reduced olfactory bulb volume compared to controls. In NBS, COVID‑19 patients showed increased structural connectivity in a subnetwork comprising parietal brain regions. Regarding global network topological properties, patients exhibited lower global and local efficiency and higher assortativity than controls. Concerning local network topological properties, patients had reduced local efficiency (left lateral orbital gyrus and pallidum), increased clustering (left lateral orbital gyrus), increased nodal strength (right anterior orbital gyrus), and reduced nodal strength (left amygdala). SS‑16 test score was negatively correlated with clustering of whole‑brain WM in the COVID‑19 group. Thus, patients with OD after COVID‑19 had relevant WM network dysfunction with increased connectivity in the parietal sensory cortex. Reduced integration and increased segregation are observed within olfactory‑related brain areas might be due to compensatory plasticity mechanisms devoted to recovering olfactory function.-
Descrição: dc.descriptionFaculdade de Medicina (FM)-
Descrição: dc.descriptionHospital Universitário de Brasília (HUB)-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherSpringer Nature-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rights(CC BY) Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/ by/4.0/.-
Palavras-chave: dc.subjectDisfunção olfativa-
Palavras-chave: dc.subjectCovid-19-
Título: dc.titleAltered structural connectivity in olfactory disfunction after mild COVID‑19 using probabilistic tractography-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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