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Metadados | Descrição | Idioma |
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Autor(es): dc.creator | Morais Júnior, Gilberto Santos | - |
Autor(es): dc.creator | Kurizky, Patricia Shu | - |
Autor(es): dc.creator | Cerqueira, Selma Regina Penha Silva | - |
Autor(es): dc.creator | Barroso, Daniel Holanda | - |
Autor(es): dc.creator | Schulte, Heidi Luise | - |
Autor(es): dc.creator | Albuquerque, Cleandro Pires de | - |
Autor(es): dc.creator | Gois, Eliana Teles de | - |
Autor(es): dc.creator | Espindola, Laila Salmen | - |
Autor(es): dc.creator | Santana, Jaime Martins de | - |
Autor(es): dc.creator | Bastos, Izabela Marques Dourado | - |
Autor(es): dc.creator | Araújo, Carla Nunes de | - |
Autor(es): dc.creator | Mota, Licia Maria Henrique da | - |
Autor(es): dc.creator | Nóbrega, Otávio de Tolêdo | - |
Autor(es): dc.creator | Gomes, Ciro Martins | - |
Data de aceite: dc.date.accessioned | 2024-10-23T16:26:53Z | - |
Data de disponibilização: dc.date.available | 2024-10-23T16:26:53Z | - |
Data de envio: dc.date.issued | 2021-07-30 | - |
Data de envio: dc.date.issued | 2021-07-30 | - |
Data de envio: dc.date.issued | 2020 | - |
Fonte completa do material: dc.identifier | https://repositorio.unb.br/handle/10482/41534 | - |
Fonte completa do material: dc.identifier | https://doi.org/10.4269/ajtmh.21-0034 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/908720 | - |
Descrição: dc.description | Experts have called attention to the possible negative impact of the coronavirus disease 2019 (COVID19)–related cytokine storm syndrome on the progression of leprosy-related disabilities. We assessed the frequency of reactional states in patients co-infected with Mycobacterium leprae and severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS-CoV-2). We consecutively included patients during the first peak of the COVID-19 epidemic in Brazil and analyzed the expressions of genes encoding interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12A, IL-12B, and tumor necrosis factor-α in peripheral blood mononuclear cells. We included 64 leprosy patients and 50 controls. Twelve of the leprosy patients and 14 of the controls had been diagnosed with COVID-19. Co-infection was associated with increased IL-6 (P = 0.043) and IL-12B (P = 0.017) expression. The median disability grades were higher for leprosy/COVID-19 patients; however, the difference was not significant (P = 0.194). Patients co-infected with M. leprae and SARS-CoV-2 may experience a higher-grade proinflammatory state. | - |
Formato: dc.format | application/pdf | - |
Publicador: dc.publisher | American Society of Tropical Medicine and Hygiene | - |
Relação: dc.relation | https://repositorio.unb.br/handle/10482/40909 | - |
Direitos: dc.rights | Acesso Aberto | - |
Direitos: dc.rights | This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | - |
Palavras-chave: dc.subject | Hanseníase | - |
Palavras-chave: dc.subject | SARS-CoV-2 | - |
Palavras-chave: dc.subject | Covid-19 | - |
Título: dc.title | Enhanced il-6 and il-12b gene expression after SARS-CoV-2 infection in leprosy patients may increase the risk of neural damage | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional – UNB |
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