Development and validation of analytical method for identification of new psychoactive substances using linear retention indexes and gas chromatography-mass spectrometry

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Autor(es): dc.contributorBrazilian Federal Police, National Institute of Criminalistics-
Autor(es): dc.contributorBrazilian Health Regulatory Agency-
Autor(es): dc.contributorUniversity of Brasília, Institute of Chemistry-
Autor(es): dc.contributorBrazilian Federal Police, National Institute of Criminalistics-
Autor(es): dc.contributorBrazilian Federal Police, National Institute of Criminalistics-
Autor(es): dc.contributorBrazilian Federal Police, National Institute of Criminalistics-
Autor(es): dc.contributorUniversity of Brasília, Institute of Chemistry-
Autor(es): dc.creatorZacca, Jorge Jardim-
Autor(es): dc.creatorGiudice, Gabriella Hamú-
Autor(es): dc.creatorSouza, Mônica P.-
Autor(es): dc.creatorCaldas, Luíza N. B.-
Autor(es): dc.creatorVieira, Maurício L.-
Autor(es): dc.creatorMachado, Ângelo Henirque de Lira-
Data de aceite: dc.date.accessioned2024-10-23T16:26:29Z-
Data de disponibilização: dc.date.available2024-10-23T16:26:29Z-
Data de envio: dc.date.issued2024-02-14-
Data de envio: dc.date.issued2024-02-14-
Data de envio: dc.date.issued2020-
Fonte completa do material: dc.identifierhttp://repositorio2.unb.br/jspui/handle/10482/47742-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.chroma.2020.461783-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/908544-
Descrição: dc.descriptionNew Psychoactive Substances (NPS) are quickly developing to evade legislation, posing unprecedented challenges to public health and law enforcement authorities around the world. The aim of this work was to develop and validate a simple and reliable non-target gas chromatography/mass spectrometry (GC/MS) analytical method based on linear retention indexes for the expeditious identification of NPS without the need of analytical standards. The method was optimized and validated for 22 different drugs covering ten categories: phenethylamines (amphetamine, MDMA, methamphetamine, 25C–NBOMe, 2-FA, 5-MAPB), “classic” drugs (cocaine, ephedrine, THC, heroine), synthetic cannabinoids (JWH-081, AM-2201, JWH-210, MAM-2201), piperazines (o-CPP, p-CPP), tryptamines (5-MeO-MiPT), synthetic cathinones (N ethylpentylone), synthetic opioids (U-47700), aminoindanes (5-IAI), plant-based substances (Salvinorin-A) and “other” (methiopropamine). Three figures of merit (Selectivity, Precision and Robustness) were eval uated with retention index confidence intervals ranging from 0.5 to 20.6 i.u. and relative standard de viations in the range of 0.003% to 0.027% (repeatability) and 0.02% to 0.29% (intermediate precision). A general equation for estimating linear retention index variation as a function of retention time tolerance has been derived. This result in combination with a 26−3 III fractional factorial design allowed to conclude column polarity to be only statistically relevant factor as compared to gas flow, split ratio, injection tem perature, temperature program offset and column brand.-
Descrição: dc.descriptionInstituto de Química (IQ)-
Descrição: dc.descriptionPrograma de Pós-Graduação em Química-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationhttps://www.sciencedirect.com/science/article/pii/S0021967320310578?via%3Dihub-
Direitos: dc.rightsAcesso Aberto-
Palavras-chave: dc.subjectCromatografia gasosa-
Palavras-chave: dc.subjectEspectrometria de massa-
Palavras-chave: dc.subjectSubstâncias psicoativas-
Título: dc.titleDevelopment and validation of analytical method for identification of new psychoactive substances using linear retention indexes and gas chromatography-mass spectrometry-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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