Positive additive and multiplicative interactions among clustered components of metabolic syndrome with type 2 diabetes mellitus among Brazilian adolescent students

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Autor(es): dc.contributormailto:rodolfodeusdara@gmail.com-
Autor(es): dc.creatorRodrigues, Rodolfo Rêgo Deusdará-
Autor(es): dc.creatorSouza, Amanda de Moura-
Autor(es): dc.creatorSzklo, Moyses-
Data de aceite: dc.date.accessioned2024-10-23T16:26:19Z-
Data de disponibilização: dc.date.available2024-10-23T16:26:19Z-
Data de envio: dc.date.issued2022-11-28-
Data de envio: dc.date.issued2022-11-28-
Data de envio: dc.date.issued2022-11-02-
Fonte completa do material: dc.identifierhttps://repositorio.unb.br/handle/10482/45232-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/nu14214640-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-1343-3265-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/908474-
Descrição: dc.descriptionBackground: It is still controversial whether the joint effect of Metabolic syndrome (MetS) components is greater than that expected based on their independent effects, regarding type 2 diabetes mellitus in adolescents. We evaluated additive and multiplicative interactions between pair-wise combinations of metabolic syndrome components regarding type 2 diabetes mellitus. Methods: We studied 37,815 Brazilian adolescents from a national school-based survey, The Study of Cardiovascular Risk Factors in Adolescents (Portuguese acronym, ERICA). A Poisson regression model was used to calculate sex-, age-, obesity-, smoking status-, sedentary behavior-, physical inactivity-, alcoholic consumption- and socioeconomic status-adjusted prevalence ratios to evaluate both additive and multiplicative interactions. Results: In the comparison of observed and expected joint effects, relative excess risk due to additive interaction (RERI) for high triglycerides and low high-density lipoprotein-cholesterol, high triglycerides and elevated waist circumference, elevated waist circumference and low high-density lipoprotein-cholesterol and elevated waist circumference and high blood pressure were 2.53 (−0.41, 5.46), 2.86 (−2.89, 8.61), 1.71 (−1.05, 4.46) and 0.97 (0.15, 1.79), respectively, thus suggesting additive interactions. Multiplicative interactions for those pairs of components were also observed, as expressed by interaction ratios > 1.0. Conclusions: The joint presence of some of the components of MetS showed a greater association with the prevalence of type 2 diabetes mellitus in adolescents than expected from the sum of their isolated effects. From a public health perspective, preventing one of the components of the pairs that interact may result in a greater reduction in the prevalence of T2DM than focusing on an individual component that does not interact with another component.-
Descrição: dc.descriptionFaculdade de Medicina (FMD)-
Formato: dc.formatapplication/pdf-
Publicador: dc.publisherMDPI-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsCopyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).-
Palavras-chave: dc.subjectSíndrome metabólica-
Palavras-chave: dc.subjectDiabetes mellitus tipo 2-
Palavras-chave: dc.subjectBiomarcadores-
Palavras-chave: dc.subjectAdolescentes - saúde e higiene-
Título: dc.titlePositive additive and multiplicative interactions among clustered components of metabolic syndrome with type 2 diabetes mellitus among Brazilian adolescent students-
Tipo de arquivo: dc.typelivro digital-
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