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Metadados | Descrição | Idioma |
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Autor(es): dc.contributor | mailto:rodolfodeusdara@gmail.com | - |
Autor(es): dc.creator | Rodrigues, Rodolfo Rêgo Deusdará | - |
Autor(es): dc.creator | Souza, Amanda de Moura | - |
Autor(es): dc.creator | Szklo, Moyses | - |
Data de aceite: dc.date.accessioned | 2024-10-23T16:26:19Z | - |
Data de disponibilização: dc.date.available | 2024-10-23T16:26:19Z | - |
Data de envio: dc.date.issued | 2022-11-28 | - |
Data de envio: dc.date.issued | 2022-11-28 | - |
Data de envio: dc.date.issued | 2022-11-02 | - |
Fonte completa do material: dc.identifier | https://repositorio.unb.br/handle/10482/45232 | - |
Fonte completa do material: dc.identifier | https://doi.org/10.3390/nu14214640 | - |
Fonte completa do material: dc.identifier | https://orcid.org/0000-0002-1343-3265 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/908474 | - |
Descrição: dc.description | Background: It is still controversial whether the joint effect of Metabolic syndrome (MetS) components is greater than that expected based on their independent effects, regarding type 2 diabetes mellitus in adolescents. We evaluated additive and multiplicative interactions between pair-wise combinations of metabolic syndrome components regarding type 2 diabetes mellitus. Methods: We studied 37,815 Brazilian adolescents from a national school-based survey, The Study of Cardiovascular Risk Factors in Adolescents (Portuguese acronym, ERICA). A Poisson regression model was used to calculate sex-, age-, obesity-, smoking status-, sedentary behavior-, physical inactivity-, alcoholic consumption- and socioeconomic status-adjusted prevalence ratios to evaluate both additive and multiplicative interactions. Results: In the comparison of observed and expected joint effects, relative excess risk due to additive interaction (RERI) for high triglycerides and low high-density lipoprotein-cholesterol, high triglycerides and elevated waist circumference, elevated waist circumference and low high-density lipoprotein-cholesterol and elevated waist circumference and high blood pressure were 2.53 (−0.41, 5.46), 2.86 (−2.89, 8.61), 1.71 (−1.05, 4.46) and 0.97 (0.15, 1.79), respectively, thus suggesting additive interactions. Multiplicative interactions for those pairs of components were also observed, as expressed by interaction ratios > 1.0. Conclusions: The joint presence of some of the components of MetS showed a greater association with the prevalence of type 2 diabetes mellitus in adolescents than expected from the sum of their isolated effects. From a public health perspective, preventing one of the components of the pairs that interact may result in a greater reduction in the prevalence of T2DM than focusing on an individual component that does not interact with another component. | - |
Descrição: dc.description | Faculdade de Medicina (FMD) | - |
Formato: dc.format | application/pdf | - |
Publicador: dc.publisher | MDPI | - |
Direitos: dc.rights | Acesso Aberto | - |
Direitos: dc.rights | Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | - |
Palavras-chave: dc.subject | Síndrome metabólica | - |
Palavras-chave: dc.subject | Diabetes mellitus tipo 2 | - |
Palavras-chave: dc.subject | Biomarcadores | - |
Palavras-chave: dc.subject | Adolescentes - saúde e higiene | - |
Título: dc.title | Positive additive and multiplicative interactions among clustered components of metabolic syndrome with type 2 diabetes mellitus among Brazilian adolescent students | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional – UNB |
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