Effect of a freeze-dried coffee solution in a high-fat diet-induced obesity model in rats : impact on inflammatory response, lipid profile, and gut microbiota

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de Brasília, Faculty of Health Sciences, Postgraduate Program in Human Nutrition-
Autor(es): dc.contributorUniversidade Federal de Viçosa, Department of Animal Science-
Autor(es): dc.contributorUniversidade de Brasília, Faculty of Health Sciences, Postgraduate Program in Human Nutrition-
Autor(es): dc.contributorUniversidade de Brasília, Faculty of Health Sciences, Postgraduate Program in Human Nutrition-
Autor(es): dc.creatorCavalcanti, Marilia Hermes-
Autor(es): dc.creatorRoseira, João Paulo Santos-
Autor(es): dc.creatorLeandro, Eliana dos Santos-
Autor(es): dc.creatorArruda, Sandra Fernandes-
Data de aceite: dc.date.accessioned2024-10-23T16:17:03Z-
Data de disponibilização: dc.date.available2024-10-23T16:17:03Z-
Data de envio: dc.date.issued2024-01-04-
Data de envio: dc.date.issued2024-01-04-
Data de envio: dc.date.issued2022-01-25-
Fonte completa do material: dc.identifierhttp://repositorio2.unb.br/jspui/handle/10482/47160-
Fonte completa do material: dc.identifierhttps://doi.org/10.1371/journal.pone.0262270-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-9826-6004-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/904448-
Descrição: dc.descriptionCoffee beans contain high polyphenol content, which have the potential to modulate the intestinal microbiota, and possibly attenuate weight gain and the associated dyslipidemia. This study investigated the effect of freeze-dried coffee solution (FCS) consumption on physiological parameters, lipid profile, and microbiota of Wistar rats fed a high-fat diet (HF) or control diet (CT). FCS combined with a high-fat diet increased the fecal and cecal Bifidobacterium spp. population and decreased the cecal Escherichia coli population and intestinal Il1b mRNA level. Regardless of the diet type, FCS increased the serum high-density lipoprotein cholesterol (HDL-C); however, it did not affect body weight, food intake, low-density lipoprotein, triglycerides, fecal bile acids, and intestinal Il6 mRNA levels. The high-fat diet increased weight gain, hepatic cholesterol and triglycerides, fecal bile acids, and the fecal and cecal Lactobacillus spp. population, and reduced food intake, the fecal E. coli population, and intestinal Il6 mRNA level. The results suggest that FCS consumption exhibits positive health effects in rats fed a high-fat diet by increasing Bifidobacterium spp. population and HDL-C reverse cholesterol transport, and by reducing Il1b mRNA level. However, FCS administration at a dose of 0.39 g/100 g diet over an eight-week period was not effective in controlling food intake, and consequently, preventing weight gain in rats of high-fat diet-induced obesity model.-
Descrição: dc.descriptionFaculdade de Ciências da Saúde (FS)-
Descrição: dc.descriptionDepartamento de Nutrição (FS NUT)-
Descrição: dc.descriptionPrograma de Pós-Graduação em Nutrição Humana-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherPlos-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rights© 2022 Cavalcanti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.-
Palavras-chave: dc.subjectDietas-
Palavras-chave: dc.subjectCafé-
Palavras-chave: dc.subjectBile-
Palavras-chave: dc.subjectBifidobactérias-
Palavras-chave: dc.subjectEscherichia coli-
Palavras-chave: dc.subjectObesidade-
Palavras-chave: dc.subjectLactobacilos-
Título: dc.titleEffect of a freeze-dried coffee solution in a high-fat diet-induced obesity model in rats : impact on inflammatory response, lipid profile, and gut microbiota-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

Não existem arquivos associados a este item.