A new design for magnetic poly(vinyl pivalate) for biomedical applications : synthesis, characterization, and evaluation of cytotoxicity in fibroblasts, keratinocytes, and human melanoma cells

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorAraújo, Robson Teixeira-
Autor(es): dc.creatorBrito Neta, Maria de Sousa-
Autor(es): dc.creatorHuamaní Coaquira, José Antonio-
Autor(es): dc.creatorChaves, Sacha Braun-
Autor(es): dc.creatorSilva, Fabricio Machado-
Data de aceite: dc.date.accessioned2024-10-23T15:54:54Z-
Data de disponibilização: dc.date.available2024-10-23T15:54:54Z-
Data de envio: dc.date.issued2022-05-31-
Data de envio: dc.date.issued2022-05-31-
Data de envio: dc.date.issued2022-01-20-
Fonte completa do material: dc.identifierhttps://repositorio.unb.br/handle/10482/43836-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/colloids6010007-
Fonte completa do material: dc.identifierhttps://orcid.org/ 0000-0002-4300-8059-
Fonte completa do material: dc.identifierhttps://orcid.org/ 0000-0002-3041-1906-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/895300-
Descrição: dc.descriptionPolymers containing magnetic properties play an important role in biomedical therapies, such as embolotherapy or hyperthermia, for their differentiated properties. In this work, magnetite (Fe3O4) nanoparticles were synthesized by the coprecipitation method and dispersed into a thermo plastic matrix of poly(vinyl pivalate) through an emulsion polymerization process. The main goal was the individual encapsulation of magnetite nanoparticles to improve the magnetic response of the magneto-polymeric materials using polymerizable carboxylic acids as coating agents, minimizing the leaching of nanoparticles throughout the nanocomposite formation. For this purpose, synthesized magnetite had its surface modified by acrylic acid or methacrylic acid to improve its individual encapsulation during the polymerization step, thus generating a series of magnetic nanocomposite materials containing different amounts of magnetite intended for biomedical applications. X-ray diffractometry and TEM measurements provided a mean size of approximately 8 nm for the pure magnetite nanoparticles and a spherical morphology. Acid-functionalized Fe3O4 had a size of ap proximately 6 nm, while the nanocomposites showed a size of approximately 7 nm. Magnetization measurement provided a saturation magnetization value of approximately 75 emu/g and confirmed superparamagnetic behavior at room temperature. DSC analysis showed a glass transition tempera ture of 65 ◦C for poly(vinyl pivalate)-based nanocomposites. The tests realized with homopolymer and magnetic composites against different cell lineages (i.e., fibroblasts, keratinocytes, and human melanoma) to evaluate the levels of cytotoxicity showed good results in the different exposure times and concentrations used, since the obtained results showed cell viability greater than 70% compared to the control group, suggesting that the synthesized materials are very promising for medical applications.-
Descrição: dc.descriptionInstituto de Química (IQ)-
Formato: dc.formatapplication/pdf-
Publicador: dc.publisherMDPI-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsCopyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/-
Palavras-chave: dc.subjectPolimerização em emulsão-
Palavras-chave: dc.subjectSuperparamagnetismo-
Palavras-chave: dc.subjectCitoxicidade-
Palavras-chave: dc.subjectHipertermia-
Palavras-chave: dc.subjectMelanoma-
Título: dc.titleA new design for magnetic poly(vinyl pivalate) for biomedical applications : synthesis, characterization, and evaluation of cytotoxicity in fibroblasts, keratinocytes, and human melanoma cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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