Specificity of the rapid rK39 antigen-based immunochromatographic test Kalazar Detect(r) in patients with cutaneous leishmaniasis in Brazil

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorMolinet, Félix Javier León-
Autor(es): dc.creatorAmpuero Vela, Julia Sonia-
Autor(es): dc.creatorCosta, Rodrigo Diniz-
Autor(es): dc.creatorNoronha, Elza Ferreira-
Autor(es): dc.creatorRomero, Gustavo Adolfo Sierra-
Data de aceite: dc.date.accessioned2024-10-23T15:51:26Z-
Data de disponibilização: dc.date.available2024-10-23T15:51:26Z-
Data de envio: dc.date.issued2017-12-07-
Data de envio: dc.date.issued2017-12-07-
Data de envio: dc.date.issued2013-05-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/28698-
Fonte completa do material: dc.identifierhttps://dx.doi.org/10.1590/S0074-02762013000300006-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/893787-
Descrição: dc.descriptionThe aim of this study was to evaluate the specificity of a rapid immunochromatographic test that was developed to detect antibodies against the rK39 antigen for the diagnosis of visceral leishmaniasis (VL). This evaluation was performed using sera from patients with a confirmed diagnosis of active cutaneous leishmaniasis. The sera from 272 patients with a confirmed diagnosis of localised cutaneous leishmaniasis (CL) who resided in an area endemic for Leishmania braziliensis in Brazil were obtained before the initiation of antileishmanial treatment. Kalazar Detect(r)(InBios, Seattle, WA) recombinant K39 antigen-based immunochromatographic strips were used according to the manufacturer's instructions. The test results were evaluated independently by two examiners in sequential order. The positive controls for the test included five serum samples from five patients with parasitologically confirmed diagnosis of VL caused by Leishmania infantum in Brazil. Overall, 100% of the samples obtained from patients with CL were negative, confirming the absence of a serological cross-reaction for individuals with cutaneous disease when these patients were evaluated using the rapid test. The lack of a cross-reaction in patients who were infected by parasites of the same genus highlights the specificity of the rK39 antigen for the diagnosis of VL in areas with the sympatric circulation of L. braziliensis and L. infantum.-
Descrição: dc.descriptionFaculdade de Medicina (FMD)-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsLICENÇAS E DIREITOS AUTORAIS Memórias do Instituto Oswaldo Cruz - Todo o conteúdo desta revista, exceto indicado de outra forma, está certificado sob uma Licença Creative Commons Attribution 4.0. Isso significa que os autores dão total permissão a qualquer pessoa para compartilhar e adaptar o conteúdo do artigo, desde que os autores originais e a fonte sejam citados. Fonte: https://www.scielo.br/journal/mioc/about/#about. Acesso em: 27 out.2022.-
Palavras-chave: dc.subjectLeishmaniose cutânea-
Palavras-chave: dc.subjectLeishmania braziliensis-
Palavras-chave: dc.subjectLeishmania infantum-
Palavras-chave: dc.subjectAntígenos-
Título: dc.titleSpecificity of the rapid rK39 antigen-based immunochromatographic test Kalazar Detect(r) in patients with cutaneous leishmaniasis in Brazil-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

Não existem arquivos associados a este item.