Hot-melt extrusion as an advantageous technology to obtain effervescent drug products

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Brasilia, School of Health Sciences, Laboratory of Food, Drug, and Cosmetics-
Autor(es): dc.contributorUniversity of Brasilia, School of Health Sciences, Laboratory of Food, Drug, and Cosmetics-
Autor(es): dc.contributorUniversity of Brasília, Faculty of Ceilândia-
Autor(es): dc.contributorUniversity of Brasília, Faculty of Ceilândia-
Autor(es): dc.contributorFederal University of Goiás, School of Pharmacy, Laboratory of Nanosystems and Drug Delivery Devices-
Autor(es): dc.contributorUniversity of Brasilia, School of Health Sciences, Laboratory of Food, Drug, and Cosmetics-
Autor(es): dc.contributorUniversity of Brasilia, School of Health Sciences, Laboratory of Food, Drug, and Cosmetics-
Autor(es): dc.contributorUniversity of Brasilia, School of Health Sciences, Laboratory of Food, Drug, and Cosmetics-
Autor(es): dc.creatorLima, Ana Luiza-
Autor(es): dc.creatorPinho, Ludmila Alvim Gomes-
Autor(es): dc.creatorChaker, Juliano Alexandre-
Autor(es): dc.creatorPinho, Ludmila Alvim Gomes-
Autor(es): dc.creatorBarreto, Livia Cristina Lira de Sá-
Autor(es): dc.creatorGratieri, Taís-
Autor(es): dc.creatorGelfuso, Guilherme Martins-
Autor(es): dc.creatorCunha Filho, Marcilio Sérgio Soares da-
Data de aceite: dc.date.accessioned2024-10-23T15:50:16Z-
Data de disponibilização: dc.date.available2024-10-23T15:50:16Z-
Data de envio: dc.date.issued2023-11-14-
Data de envio: dc.date.issued2023-11-14-
Data de envio: dc.date.issued2020-08-17-
Fonte completa do material: dc.identifierhttp://repositorio2.unb.br/jspui/handle/10482/46862-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/pharmaceutics12080779-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-2177-8941-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-4801-2145-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-1924-7885-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-9167-6852-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/893260-
Descrição: dc.descriptionHere, we assessed the feasibility of hot-melt extrusion (HME) to obtain effervescent drug products for the first time. For this, a combined mixture design was employed using paracetamol as a model drug. Extrudates were obtained under reduced torque (up to 0.3 Nm) at 100 ◦C to preserve the stability of the effervescent salts. Formulations showed vigorous and rapid effervescent disintegration (<3 min), adequate flow characteristics, and complete solubilization of paracetamol instantly after the effervescent reaction. Formulations containing PVPVA in the concentration range of 15–20% m/m were demonstrated to be sensitive to accelerated aging conditions, undergoing marked microstructural changes, since the capture of water led to the agglomeration and loss of their functional characteristics. HPMC matrices, in contrast, proved to be resistant to storage conditions in high relative humidity, showing superior performance to controls, including the commercial product. Moreover, the combined mixture design allowed us to identify significant interactions between the polymeric materials and the disintegrating agents, showing the formulation regions in which the responses are kept within the required levels. In conclusion, this study demonstrates that HME can bring important benefits to the elaboration of effervescent drug products, simplifying the production process and obtaining formulations with improved characteristics, such as faster disintegration, higher drug solubilization, and better stability.-
Descrição: dc.descriptionFaculdade de Ciências da Saúde (FS)-
Descrição: dc.descriptionDepartamento de Farmácia (FS FAR)-
Descrição: dc.descriptionFaculdade UnB Ceilândia (FCE)-
Descrição: dc.descriptionColegiado de Bases Biológicas e da Saúde (FCE-BASES)-
Formato: dc.formatapplication/pdf-
Idioma: dc.languagept_BR-
Publicador: dc.publisherMDPI-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rights© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).-
Palavras-chave: dc.subjectExtrusão por fusão a quente-
Palavras-chave: dc.subjectMedicamentos efervescentes-
Título: dc.titleHot-melt extrusion as an advantageous technology to obtain effervescent drug products-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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