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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Santana, Washington Macedo de | - |
Autor(es): dc.creator | Sousa, Dircilei Nascimento de | - |
Autor(es): dc.creator | Ferreira, Vania Maria Moraes | - |
Autor(es): dc.creator | Duarte, Wagner Rodrigues | - |
Data de aceite: dc.date.accessioned | 2024-10-23T15:48:55Z | - |
Data de disponibilização: dc.date.available | 2024-10-23T15:48:55Z | - |
Data de envio: dc.date.issued | 2017-12-07 | - |
Data de envio: dc.date.issued | 2017-12-07 | - |
Data de envio: dc.date.issued | 2016-05 | - |
Fonte completa do material: dc.identifier | http://repositorio.unb.br/handle/10482/30182 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1590/S0102-865020160050000002 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/892683 | - |
Descrição: dc.description | Purpose: to investigate the effects of locally applied simvastatin plus biphasic calcium phosphate (BoneCeramic(r)) or collagen sponge on bone formation in critical-sized bone defects. Methods: thirty defects of 5mm in diameter were created bilaterally with a trephine bur in the calvariae of fifteen Wistar rats. The defects were divided into five groups: group 1 - control, no treatment; group 2 (BoneCeramic(r)); group 3 (BoneCeramic(r) + 0.1mg simvastatin); group 4 (collagen sponge); and group 5 (collagen sponge + 0.1mg simvastatin). After eight weeks the animals were euthanized and their calvariae were histologically processed. Hematoxylin and eosin-stained sections were subjected to histological and histomorphometrical analyses. The area of newly formed bone was calculated and compared between groups. Results: the greater amount of a bone-like tissue was formed around the carrier in group 3 (BoneCeramic(r) + 0.1mg simvastatin) followed by group 2 (BoneCeramic(r)), and almost no bone was formed in the other groups. Group 3 was significantly different compared to group 2, and both groups were significantly different compared to the other groups. Conclusion: simvastatin combined with BoneCeramic(r) induced significantly greater amounts of newly formed bone and has great potential for the healing of bone defects. | - |
Formato: dc.format | application/pdf | - |
Idioma: dc.language | en | - |
Publicador: dc.publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia | - |
Direitos: dc.rights | Acesso Aberto | - |
Direitos: dc.rights | Acta Cirurgica Brasileira - This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000500300&lng=en&nrm=iso. Acesso em: 6 mar. 2018. | - |
Palavras-chave: dc.subject | Cálcio | - |
Palavras-chave: dc.subject | Ossos - crescimento | - |
Palavras-chave: dc.subject | Ratos | - |
Título: dc.title | Simvastatin and biphasic calcium phosphate affects bone formation in critical-sized rat calvarial defects | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional – UNB |
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