Chemical and biological evaluation of amazonian medicinal plant vouacapoua americana aubl

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Autor(es): dc.contributorKiel University, Department of Pharmaceutical Biology-
Autor(es): dc.contributorKiel University, Department of Pharmaceutical Biology-
Autor(es): dc.contributorGEOMAR Helmholtz Centre for Ocean Research Kiel, GEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Research Unit Marine Natural Products Chemistry-
Autor(es): dc.contributorBrazilian Agricultural Research Corporation, Ecoregional Research Unit-
Autor(es): dc.contributorFederal University of Amapá, Laboratory of Bioprospection and Atomic Absorption-
Autor(es): dc.contributorKiel University, Otto Diels Institute for Organic Chemistry-
Autor(es): dc.contributorKiel University, Department of Pharmaceutical Biology-
Autor(es): dc.contributorUniversity of Brasilia, Darcy Ribeiro Campus, Laboratory of Bioprospection-
Autor(es): dc.contributorGEOMAR Helmholtz Centre for Ocean Research Kiel, GEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Research Unit Marine Natural Products Chemistry-
Autor(es): dc.contributorKiel University, Faculty of Mathematics and Natural Sciences-
Autor(es): dc.creatorÇiçek, Serhat Sezai-
Autor(es): dc.creatorBarbosa, Anna Laís Pfeifer-
Autor(es): dc.creatorWenzel-Storjohann, Arlette-
Autor(es): dc.creatorSegovia, Jorge Federico Orellana-
Autor(es): dc.creatorBezerra, Roberto Messias-
Autor(es): dc.creatorSönnichsen, Frank-
Autor(es): dc.creatorZidorn, Christian-
Autor(es): dc.creatorKanzaki, Isamu-
Autor(es): dc.creatorTasdemir, Deniz-
Data de aceite: dc.date.accessioned2024-10-23T15:45:07Z-
Data de disponibilização: dc.date.available2024-10-23T15:45:07Z-
Data de envio: dc.date.issued2024-03-25-
Data de envio: dc.date.issued2024-03-25-
Data de envio: dc.date.issued2022-12-24-
Fonte completa do material: dc.identifierhttp://repositorio2.unb.br/jspui/handle/10482/48026-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/plants12010099-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-3038-8523-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-4539-3755-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-8956-9874-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-7841-6271-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/891051-
Descrição: dc.descriptionVouacapoua americana (Fabaceae) is an economically important tree in the Amazon region and used for its highly resistant heartwood as well as for medicinal purposes. Despite its frequent use, phytochemical investigations have been limited and rather focused on ecological properties than on its pharmacological potential. In this study, we investigated the phytochemistry and bioactivity of V. americana stem bark extract and its constituents to identify eventual lead structures for further drug development. Applying hydrodistillation and subsequent GC-MS analysis, we investigated the composition of the essential oil and identified the 15 most abundant components. Moreover, the diterpenoids deacetylchagresnone (1), cassa-13(14),15-dien-oic acid (2), isoneocaesalpin H (3), (+)-vouacapenic acid (4), and (+)-methyl vouacapenate (5) were isolated from the stem bark, with compounds 2 and 4 showing pronounced effects on Methicillin-resistant Staphylococcus aureus and Enterococcus faecium, respectively. During the structure elucidation of deacetylchagresnone (1), which was isolated from a natural source for the first time, we detected inconsistencies regarding the configuration of the cyclopropane ring. Thus, the structure was revised for both deacetylchagresnone (1) and the previously isolated chagresnone. Following our works on Copaifera reticulata and Vatairea guianensis, the results of this study further contribute to the knowledge of Amazonian medicinal plants.-
Descrição: dc.descriptionFaculdade de Ciências da Saúde (FS)-
Descrição: dc.descriptionDepartamento de Farmácia (FS FAR)-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherMDPI-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).-
Palavras-chave: dc.subjectAntimicrobiano-
Palavras-chave: dc.subjectAcapu-
Palavras-chave: dc.subjectPlantas medicinais-
Título: dc.titleChemical and biological evaluation of amazonian medicinal plant vouacapoua americana aubl-
Tipo de arquivo: dc.typelivro digital-
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