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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Uint, Luciana | - |
Autor(es): dc.creator | Spósito, Andrei Carvalho | - |
Autor(es): dc.creator | Brandizzi, Laura Ines Ventura | - |
Autor(es): dc.creator | Yoshida, Vanda Mitie | - |
Autor(es): dc.creator | Maranhão, Raul Cavalcante | - |
Autor(es): dc.creator | Luz, Protásio Lemos da | - |
Data de aceite: dc.date.accessioned | 2024-10-23T15:44:59Z | - |
Data de disponibilização: dc.date.available | 2024-10-23T15:44:59Z | - |
Data de envio: dc.date.issued | 2010-03-26 | - |
Data de envio: dc.date.issued | 2010-03-26 | - |
Data de envio: dc.date.issued | 2003 | - |
Fonte completa do material: dc.identifier | http://repositorio.unb.br/handle/10482/4025 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/890994 | - |
Descrição: dc.description | 3 f. : il. | - |
Descrição: dc.description | OBJECTIVE: The aim of this study was to verify whether HDL particles isolated from patients with coronary artery disease (CAD) and low HDL-C had diminished ability to promote cholesterol efflux from cultured cells compared with HDL isolated from subjects without CAD and with normal HDL-C. METHODS: Smooth muscle cells isolated from human aortas cultured and radiolabeled with ³H-cholesterol were loaded with cholesterol and incubated with increasing concentrations of HDL isolated from 13 CAD patients with low HDL-C (CAD group) or from 5 controls without CAD (C group). Efflux of cellular cholesterol was measured by cellular depletion of radiolabeled cholesterol and by the appearance of ³H-cholesterol into experimental medium expressed as a percentage of total labeled cholesterol. RESULTS: Cholesterol efflux increased with the amount of HDL present in the medium, and no difference was found between groups at various HDL protein concentrations: efflux was 28 ± 6.3 percent (C) and 25.5 ± 8.9 percent (CAD) with 25 mg/mL; 34 ± 4.3 percent (C) and 31.9 ± 6.6 percent (CD) with 50 mg/mL and 39.5 ± 3.5 percent (C) and 37.1 ± 4.4 percent (CAD) with 100 mg/mL, HDL. CONCLUSION: Because the HDL fraction of CAD patients with low HDL-C have normal ability to extract cholesterol from cells of the vessel wall, it is suggested that low HDL-C atherogenicity should be ascribed to diminished concentrations of HDL particles rather than to the qualitative properties of the HDL fraction (AU). | - |
Descrição: dc.description | Faculdade de Medicina (FMD) | - |
Formato: dc.format | application/pdf | - |
Direitos: dc.rights | Acesso Aberto | - |
Palavras-chave: dc.subject | Coronariopatias | - |
Palavras-chave: dc.subject | Colesterol | - |
Palavras-chave: dc.subject | Lipoproteínas | - |
Palavras-chave: dc.subject | Artérias | - |
Título: dc.title | Cellular cholesterol efflux mediated by HDL isolated from subjects with low HDL levels and Coronary artery disease | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional – UNB |
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