UV-accelerated synthesis of gold nanoparticle–pluronic nanocomposites for X-ray computed tomography contrast enhancement

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de Brasilia, Instituto de Física, Laboratório de Nanofilmes e Nano Dispositivos-
Autor(es): dc.contributorInstituto Federal de Educação, Ciência e Tecnologia de Rôndonia-
Autor(es): dc.contributorUniversidade de Brasilia, Instituto de Quimica, Laboratorio de Pesquisa em Polimeros e Nanomateriais-
Autor(es): dc.contributorUniversidade de Brasilia, Instituto de Física, Laboratório de Nanofilmes e Nano Dispositivos-
Autor(es): dc.contributorUniversidade de Brasilia, Instituto de Física, Laboratório de Nanofilmes e Nano Dispositivos-
Autor(es): dc.contributorFederal University of Mato Grosso, Institute of Biological and Health Sciences, Laboratory of System Physiology and Reproductive Toxicology-
Autor(es): dc.contributorFederal University of Mato Grosso, Institute of Biological and Health Sciences, Laboratory of System Physiology and Reproductive Toxicology-
Autor(es): dc.contributorFederal University of Mato Grosso, Institute of Biological and Health Sciences, Laboratory of System Physiology and Reproductive Toxicology-
Autor(es): dc.contributorUniversidade de Brasilia, Instituto de Ciências Biológicas, Departamento de Biologia Celular, Laboratório de Biofisica Molecular-
Autor(es): dc.contributorUniversidade de Brasilia, Instituto de Ciências Biologicas-
Autor(es): dc.contributorUniversidade Federal de Goiás, Instituto de Quimica-
Autor(es): dc.contributorInstitut de Physique et Chimie des Materiaux de Strasbourg (IPCMS), UMR-7504 CNRS-Universite de Strasbourg-
Autor(es): dc.contributorFederal University of Mato Grosso, Institute of Biological and Health Sciences, Laboratory of System Physiology and Reproductive Toxicology-
Autor(es): dc.contributorUniversidade de Brasilia, Instituto de Ciências Biológicas, Departamento de Biologia Celular, Laboratório de Biofisica Molecular-
Autor(es): dc.contributorUniversidade de Brasilia, Instituto de Física, Laboratório de Nanofilmes e Nano Dispositivos-
Autor(es): dc.creatorGomes, Deizilene de Souza Barbosa-
Autor(es): dc.creatorPatermo, Leonardo Giordano-
Autor(es): dc.creatorSantos, Aline B. S.-
Autor(es): dc.creatorBarbosa, Débora P. P.-
Autor(es): dc.creatorHoltz, Beatriz M.-
Autor(es): dc.creatorSouza, Maysa R.-
Autor(es): dc.creatorSouza, Rafaianne Q. Moraes-
Autor(es): dc.creatorGaray, Aisel V.-
Autor(es): dc.creatorAndrade, Laise R. de-
Autor(es): dc.creatorSartoratto, Patricia P. C.-
Autor(es): dc.creatorMertz, Damien-
Autor(es): dc.creatorVolpato, Gustavo T.-
Autor(es): dc.creatorFreitas, Sonia M.-
Autor(es): dc.creatorSoler, Maria Aparecida Godoy-
Data de aceite: dc.date.accessioned2024-10-23T15:43:28Z-
Data de disponibilização: dc.date.available2024-10-23T15:43:28Z-
Data de envio: dc.date.issued2023-10-23-
Data de envio: dc.date.issued2023-10-23-
Data de envio: dc.date.issued2023-05-01-
Fonte completa do material: dc.identifierhttp://repositorio2.unb.br/jspui/handle/10482/46724-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/polym15092163-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-7716-0318-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-2144-5004-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-3639-5740-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-6947-1087-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-6745-8978-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-4753-3264-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-7562-4980-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-0444-873X-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/890295-
Descrição: dc.descriptionEco-friendly chemical methods using FDA-approved Pluronic F127 (PLU) block copolymer have garnered much attention for simultaneously forming and stabilizing Au nanoparticles (AuNPs). Given the remarkable properties of AuNPs for usage in various fields, especially in biomedicine, we performed a systematic study to synthesize AuNP-PLU nanocomposites under optimized conditions using UV irradiation for accelerating the reaction. The use of UV irradiation at 254 nm resulted in several advantages over the control method conducted under ambient light (control). The AuNP-PLU-UV nanocomposite was produced six times faster, lasting 10 min, and exhibited lower size dispersion than the control. A set of experimental techniques was applied to determine the structure and morphology of the produced nanocomposites as affected by the UV irradiation. The MTT assay was conducted to estimate IC50 values of AuNP-PLU-UV in NIH 3T3 mouse embryonic fibroblasts, and the results suggest that the sample is more compatible with cells than control samples. Afterward, in vivo maternal and fetal toxicity assays were performed in rats to evaluate the effect of AuNP-PLU-UV formulation during pregnancy. Under the tested conditions, the treatment was found to be safe for the mother and fetus. As a proof of concept or application, the synthesized Au:PLU were tested as contrast agents with an X-ray computed tomography scan (X-ray CT).-
Descrição: dc.descriptionInstituto de Física (IF)-
Descrição: dc.descriptionInstituto de Química (IQ)-
Descrição: dc.descriptionInstituto de Ciências Biológicas (IB)-
Descrição: dc.descriptionDepartamento de Biologia Celular (IB CEL)-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherMDPI-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).-
Palavras-chave: dc.subjectNanopartículas de ouro-
Palavras-chave: dc.subjectPluronic F127-
Palavras-chave: dc.subjectNanocompósitos-
Palavras-chave: dc.subjectTomografia computadorizada-
Palavras-chave: dc.subjectCitotoxicidade-
Título: dc.titleUV-accelerated synthesis of gold nanoparticle–pluronic nanocomposites for X-ray computed tomography contrast enhancement-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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