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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Oliveira, Jade de | - |
Autor(es): dc.creator | Engel, Daiane F. | - |
Autor(es): dc.creator | Paula, Gabriela C. de | - |
Autor(es): dc.creator | Santos, Danubia B. dos | - |
Autor(es): dc.creator | Lopes, Jadna B. | - |
Autor(es): dc.creator | Farina, Marcelo | - |
Autor(es): dc.creator | Moreira, Eduardo L. G. | - |
Autor(es): dc.creator | Bem, Andreza Fabro de | - |
Data de aceite: dc.date.accessioned | 2024-10-23T15:42:50Z | - |
Data de disponibilização: dc.date.available | 2024-10-23T15:42:50Z | - |
Data de envio: dc.date.issued | 2021-10-14 | - |
Data de envio: dc.date.issued | 2021-10-14 | - |
Data de envio: dc.date.issued | 2020-10-26 | - |
Fonte completa do material: dc.identifier | https://repositorio.unb.br/handle/10482/42136 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/890018 | - |
Descrição: dc.description | Background: Evidence has revealed an association between familial hypercholesterolemia and cognitive impairment. In this regard, a connection between cognitive deficits and hippocampal blood-brain barrier (BBB) breakdown was found in low-density lipoprotein receptor knockout mice (LDLr–/–), a mouse model of familial hypercholesterolemia. Objective: Herein we investigated the impact of a hypercholesterolemic diet on cognition and BBB function in C57BL/6 wild-type and LDLr–/– mice. Methods: Animals were fed with normal or high cholesterol diets for 30 days. Thus, wild-type and LDLr–/– mice were submitted to memory paradigms. Additionally, BBB integrity was evaluated in the mice’s prefrontal cortices and hippocampi. Results: A tenfold elevation in plasma cholesterol levels of LDLr–/– mice was observed after a hypercholesterolemic diet, while in wild-type mice, the hypercholesterolemic diet exposure increased plasma cholesterol levels only moderately and did not induce cognitive impairment. LDLr–/– mice presented memory impairment regardless of the diet. We observed BBB disruption as an increased permeability to sodium fluorescein in the prefrontal cortices and hippocampi and a decrease on hippocampal claudin-5 and occludin mRNA levels in both wild-type and LDLr–/– mice treated with a hypercholesterolemic diet. The LDLr–/– mice fed with a regular diet already presented BBB dysfunction. The BBB-increased leakage in the hippocampi of LDLr–/– mice was related to high microvessel content and intense astrogliosis, which did not occur in the control mice. Conclusion: Therefore, LDLr–/– mice seem to be more susceptible to cognitive impairments and BBB damage induced by exposure to a high cholesterol diet. Finally, BBB disruption appears to be a relevant event in hypercholesterolemia-induced brain alterations. | - |
Formato: dc.format | application/pdf | - |
Publicador: dc.publisher | IOS Press | - |
Direitos: dc.rights | Acesso Aberto | - |
Direitos: dc.rights | © 2020 – IOS Press and the authors. All rights reserved. This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0). | - |
Palavras-chave: dc.subject | Barreira hemencefálica | - |
Palavras-chave: dc.subject | Hipercolesterolemia familiar | - |
Palavras-chave: dc.subject | Camundongos | - |
Palavras-chave: dc.subject | Memória | - |
Palavras-chave: dc.subject | Prejuízo cognitivo leve | - |
Palavras-chave: dc.subject | Neuroinflamação | - |
Título: dc.title | High cholesterol diet exacerbates blood-brain barrier disruption in LDLr–/– mice : impact on cognitive function | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional – UNB |
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