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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Teixeira, Marcus de Melo | - |
Autor(es): dc.creator | Almeida, Luiz G. P. de | - |
Autor(es): dc.creator | Barreira, Paula Kubitschek | - |
Autor(es): dc.creator | Alves, Fernanda L. | - |
Autor(es): dc.creator | Kioshima, Érika Seki | - |
Autor(es): dc.creator | Abadio, Ana Karina Rodrigues | - |
Autor(es): dc.creator | Fernandes, Larissa | - |
Autor(es): dc.creator | Derengowski, Lorena da Silveira | - |
Autor(es): dc.creator | Ferreira, Karen Spadari | - |
Autor(es): dc.creator | Souza, Rangel C. | - |
Autor(es): dc.creator | Ruiz, Jerônimo Conceição | - |
Autor(es): dc.creator | Andrade, Nathália Curty De | - |
Autor(es): dc.creator | Paes, Hugo Costa | - |
Autor(es): dc.creator | Nicola, André Moraes | - |
Autor(es): dc.creator | Albuquerque, Patrícia | - |
Autor(es): dc.creator | Gerber, Alexandra Lehmkuhl | - |
Autor(es): dc.creator | Martins, Vicente de Paulo | - |
Autor(es): dc.creator | Peconick, Luísa Defranco Ferreira | - |
Autor(es): dc.creator | Viggiano Neto, Alan | - |
Autor(es): dc.creator | Chaucanez, Claudia B. | - |
Autor(es): dc.creator | Silva, Patrícia Alves | - |
Autor(es): dc.creator | Cunha, Oberdan L. | - |
Autor(es): dc.creator | Oliveira, Fabiana Freire Mendes de | - |
Autor(es): dc.creator | Santos, Tayná Cristina dos | - |
Autor(es): dc.creator | Barros, Amanda Lira Nogueira | - |
Autor(es): dc.creator | Soares, Marcos Antônio | - |
Autor(es): dc.creator | Oliveira, Luciana M. de | - |
Autor(es): dc.creator | Marini, Marjorie Mendes | - |
Autor(es): dc.creator | Duno, Héctor Villalobos | - |
Autor(es): dc.creator | Cunha, Marcel Menezes Lyra da | - |
Autor(es): dc.creator | Hoog, Sybren de | - |
Autor(es): dc.creator | Silveira, José Franco da | - |
Autor(es): dc.creator | Henrissat, Bernard | - |
Autor(es): dc.creator | Niño Vega, Gustavo A. | - |
Autor(es): dc.creator | Cisalpino, Patrícia Silva | - |
Autor(es): dc.creator | Montes, Héctor Manuel Mora | - |
Autor(es): dc.creator | Almeida, Sandro Rogério de | - |
Autor(es): dc.creator | Stajich, Jason E. | - |
Autor(es): dc.creator | Bezerra, Leila Maria Lopes | - |
Autor(es): dc.creator | Vasconcelos, Ana Tereza Ribeiro de | - |
Autor(es): dc.creator | Felipe, Maria Sueli Soares | - |
Data de aceite: dc.date.accessioned | 2024-10-23T15:40:23Z | - |
Data de disponibilização: dc.date.available | 2024-10-23T15:40:23Z | - |
Data de envio: dc.date.issued | 2017-07-10 | - |
Data de envio: dc.date.issued | 2017-07-10 | - |
Data de envio: dc.date.issued | 2014-09-25 | - |
Fonte completa do material: dc.identifier | http://repositorio.unb.br/handle/10482/23801 | - |
Fonte completa do material: dc.identifier | https://dx.doi.org/10.1186/1471-2164-15-943 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/888955 | - |
Descrição: dc.description | Background: The fungal genus Sporothrix includes at least four human pathogenic species. One of these species, S. brasiliensis, is the causal agent of a major ongoing zoonotic outbreak of sporotrichosis in Brazil. Elsewhere, sapronoses are caused by S. schenckii and S. globosa. The major aims on this comparative genomic study are: 1) to explore the presence of virulence factors in S. schenckii and S. brasiliensis; 2) to compare S. brasiliensis, which is cat-transmitted and infects both humans and cats with S. schenckii, mainly a human pathogen; 3) to compare these two species to other human pathogens (Onygenales) with similar thermo-dimorphic behavior and to other plant-associated Sordariomycetes. Results: The genomes of S. schenckii and S. brasiliensis were pyrosequenced to 17x and 20x coverage comprising a total of 32.3 Mb and 33.2 Mb, respectively. Pair-wise genome alignments revealed that the two species are highly syntenic showing 97.5% average sequence identity. Phylogenomic analysis reveals that both species diverged about 3.8-4.9 MYA suggesting a recent event of speciation. Transposable elements comprise respectively 0.34% and 0.62% of the S. schenckii and S. brasiliensis genomes and expansions of Gypsy-like elements was observed reflecting the accumulation of repetitive elements in the S. brasiliensis genome. Mitochondrial genomic comparisons showed the presence of group-I intron encoding homing endonucleases (HE’s) exclusively in S. brasiliensis. Analysis of protein family expansions and contractions in the Sporothrix lineage revealed expansion of LysM domain-containing proteins, small GTPases, PKS type1 and leucin-rich proteins. In contrast, a lack of polysaccharide lyase genes that are associated with decay of plants was observed when compared to other Sordariomycetes and dimorphic fungal pathogens, suggesting evolutionary adaptations from a plant pathogenic or saprobic to an animal pathogenic life style. Conclusions: Comparative genomic data suggest a unique ecological shift in the Sporothrix lineage from plantassociation to mammalian parasitism, which contributes to the understanding of how environmental interactions may shape fungal virulence. . Moreover, the striking differences found in comparison with other dimorphic fungi revealed that dimorphism in these close relatives of plant-associated Sordariomycetes is a case of convergent evolution, stressing the importance of this morphogenetic change in fungal pathogenesis. | - |
Formato: dc.format | application/pdf | - |
Publicador: dc.publisher | BioMed Central | - |
Direitos: dc.rights | Acesso Aberto | - |
Direitos: dc.rights | © 2014 Teixeira et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | - |
Palavras-chave: dc.subject | Fungos - doenças | - |
Palavras-chave: dc.subject | Gato | - |
Palavras-chave: dc.subject | Plantas | - |
Título: dc.title | Comparative genomics of the major fungal agents of human and animal Sporotrichosis : Sporothrix schenckii and Sporothrix brasiliensis | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional – UNB |
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