Comparative genomics of the major fungal agents of human and animal Sporotrichosis : Sporothrix schenckii and Sporothrix brasiliensis

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Autor(es): dc.creatorTeixeira, Marcus de Melo-
Autor(es): dc.creatorAlmeida, Luiz G. P. de-
Autor(es): dc.creatorBarreira, Paula Kubitschek-
Autor(es): dc.creatorAlves, Fernanda L.-
Autor(es): dc.creatorKioshima, Érika Seki-
Autor(es): dc.creatorAbadio, Ana Karina Rodrigues-
Autor(es): dc.creatorFernandes, Larissa-
Autor(es): dc.creatorDerengowski, Lorena da Silveira-
Autor(es): dc.creatorFerreira, Karen Spadari-
Autor(es): dc.creatorSouza, Rangel C.-
Autor(es): dc.creatorRuiz, Jerônimo Conceição-
Autor(es): dc.creatorAndrade, Nathália Curty De-
Autor(es): dc.creatorPaes, Hugo Costa-
Autor(es): dc.creatorNicola, André Moraes-
Autor(es): dc.creatorAlbuquerque, Patrícia-
Autor(es): dc.creatorGerber, Alexandra Lehmkuhl-
Autor(es): dc.creatorMartins, Vicente de Paulo-
Autor(es): dc.creatorPeconick, Luísa Defranco Ferreira-
Autor(es): dc.creatorViggiano Neto, Alan-
Autor(es): dc.creatorChaucanez, Claudia B.-
Autor(es): dc.creatorSilva, Patrícia Alves-
Autor(es): dc.creatorCunha, Oberdan L.-
Autor(es): dc.creatorOliveira, Fabiana Freire Mendes de-
Autor(es): dc.creatorSantos, Tayná Cristina dos-
Autor(es): dc.creatorBarros, Amanda Lira Nogueira-
Autor(es): dc.creatorSoares, Marcos Antônio-
Autor(es): dc.creatorOliveira, Luciana M. de-
Autor(es): dc.creatorMarini, Marjorie Mendes-
Autor(es): dc.creatorDuno, Héctor Villalobos-
Autor(es): dc.creatorCunha, Marcel Menezes Lyra da-
Autor(es): dc.creatorHoog, Sybren de-
Autor(es): dc.creatorSilveira, José Franco da-
Autor(es): dc.creatorHenrissat, Bernard-
Autor(es): dc.creatorNiño Vega, Gustavo A.-
Autor(es): dc.creatorCisalpino, Patrícia Silva-
Autor(es): dc.creatorMontes, Héctor Manuel Mora-
Autor(es): dc.creatorAlmeida, Sandro Rogério de-
Autor(es): dc.creatorStajich, Jason E.-
Autor(es): dc.creatorBezerra, Leila Maria Lopes-
Autor(es): dc.creatorVasconcelos, Ana Tereza Ribeiro de-
Autor(es): dc.creatorFelipe, Maria Sueli Soares-
Data de aceite: dc.date.accessioned2024-10-23T15:40:23Z-
Data de disponibilização: dc.date.available2024-10-23T15:40:23Z-
Data de envio: dc.date.issued2017-07-10-
Data de envio: dc.date.issued2017-07-10-
Data de envio: dc.date.issued2014-09-25-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/23801-
Fonte completa do material: dc.identifierhttps://dx.doi.org/10.1186/1471-2164-15-943-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/888955-
Descrição: dc.descriptionBackground: The fungal genus Sporothrix includes at least four human pathogenic species. One of these species, S. brasiliensis, is the causal agent of a major ongoing zoonotic outbreak of sporotrichosis in Brazil. Elsewhere, sapronoses are caused by S. schenckii and S. globosa. The major aims on this comparative genomic study are: 1) to explore the presence of virulence factors in S. schenckii and S. brasiliensis; 2) to compare S. brasiliensis, which is cat-transmitted and infects both humans and cats with S. schenckii, mainly a human pathogen; 3) to compare these two species to other human pathogens (Onygenales) with similar thermo-dimorphic behavior and to other plant-associated Sordariomycetes. Results: The genomes of S. schenckii and S. brasiliensis were pyrosequenced to 17x and 20x coverage comprising a total of 32.3 Mb and 33.2 Mb, respectively. Pair-wise genome alignments revealed that the two species are highly syntenic showing 97.5% average sequence identity. Phylogenomic analysis reveals that both species diverged about 3.8-4.9 MYA suggesting a recent event of speciation. Transposable elements comprise respectively 0.34% and 0.62% of the S. schenckii and S. brasiliensis genomes and expansions of Gypsy-like elements was observed reflecting the accumulation of repetitive elements in the S. brasiliensis genome. Mitochondrial genomic comparisons showed the presence of group-I intron encoding homing endonucleases (HE’s) exclusively in S. brasiliensis. Analysis of protein family expansions and contractions in the Sporothrix lineage revealed expansion of LysM domain-containing proteins, small GTPases, PKS type1 and leucin-rich proteins. In contrast, a lack of polysaccharide lyase genes that are associated with decay of plants was observed when compared to other Sordariomycetes and dimorphic fungal pathogens, suggesting evolutionary adaptations from a plant pathogenic or saprobic to an animal pathogenic life style. Conclusions: Comparative genomic data suggest a unique ecological shift in the Sporothrix lineage from plantassociation to mammalian parasitism, which contributes to the understanding of how environmental interactions may shape fungal virulence. . Moreover, the striking differences found in comparison with other dimorphic fungi revealed that dimorphism in these close relatives of plant-associated Sordariomycetes is a case of convergent evolution, stressing the importance of this morphogenetic change in fungal pathogenesis.-
Formato: dc.formatapplication/pdf-
Publicador: dc.publisherBioMed Central-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rights© 2014 Teixeira et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.-
Palavras-chave: dc.subjectFungos - doenças-
Palavras-chave: dc.subjectGato-
Palavras-chave: dc.subjectPlantas-
Título: dc.titleComparative genomics of the major fungal agents of human and animal Sporotrichosis : Sporothrix schenckii and Sporothrix brasiliensis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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