Cytokines and dysregulation of the immune response in human malaria

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorAlves, Maria de Fátima Costa-
Autor(es): dc.creatorSantos Neto, Leopoldo Luiz dos-
Autor(es): dc.creatorMuniz-Junqueira, Maria Imaculada-
Autor(es): dc.creatorTosta, Carlos Eduardo-
Data de aceite: dc.date.accessioned2024-10-23T15:40:08Z-
Data de disponibilização: dc.date.available2024-10-23T15:40:08Z-
Data de envio: dc.date.issued2010-10-28-
Data de envio: dc.date.issued2010-10-28-
Data de envio: dc.date.issued1992-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/5794-
Fonte completa do material: dc.identifierhttps://dx.doi.org/10.1590/S0074-02761992000700055-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/888844-
Descrição: dc.descriptionABSTRACT: The dysregulation of the immune response by malaria parasite has been considered as a possible constraint to the effectiveness of malaria vaccination. In spite of the important role interleukin-I (IL-1) in malaria are lacking. We found that only 2 out of 35 subjectswith acute malaria showed increased levels of serum IL-1 α by enzyme immunoassay. To assess whether IL-1 could interfere with T- lymphocyte responses, blood mononuclear cells from patients infected with Plasmodium falciparum, P. vivax, or healthy subjects were cultured with phytohemagglutinin, and lymphocyte proliferation measured 72h later by 3H-thymidine incorporation. Our data showed that T-lymphocyte responses are depressed both in P. falciparum (10,500 ñ 2,900) and P. vivax malaria (13,000 ñ 3,300), as compared to that of healthy individuals (27,000 ñ 3,000). Addition of IL-1 partially reserved depression of malaria lymphocytes, but had no effect on normal cells. On the other hand, T-lymphocytes from malaria infected-subjects presented a minimal decrease in proliferation, when cultured in the presence of exogenous PGE2. These data indicate the occurrence of two defects of immunoregulation in malaria: a deficiency of IL-1 production by monocytes/macrophages, and an increased resistance of lymphocytes to the antiproliferative effect of PGE2.-
Descrição: dc.descriptionFaculdade de Medicina (FMD)-
Formato: dc.formatapplication/pdf-
Direitos: dc.rightsAcesso Aberto-
Palavras-chave: dc.subjectCytokines-
Palavras-chave: dc.subjectImmune response-
Palavras-chave: dc.subjectPlasmodium falciparum-
Palavras-chave: dc.subjectPlasmodium vivax-
Título: dc.titleCytokines and dysregulation of the immune response in human malaria-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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