Real-life quantitative G6PD screening in Plasmodium vivax patients in the Brazilian Amazon : a cost-effectiveness analysis

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorInstituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Dourado-
Autor(es): dc.contributorUniversidade do Estado do Amazonas, Escola Superior de Ciências da Saúde-
Autor(es): dc.contributorUniversidade de Brasilia, Faculdade de Medicina-
Autor(es): dc.contributorCharles Darwin University, Global and Tropical Health Division, Menzies School of Health Research-
Autor(es): dc.contributorUniversity of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health-
Autor(es): dc.contributorInstituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Dourado-
Autor(es): dc.contributorUniversidade do Estado do Amazonas, Escola Superior de Ciências da Saúde-
Autor(es): dc.contributorInstituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Dourado-
Autor(es): dc.contributorUniversidade do Estado do Amazonas, Escola Superior de Ciências da Saúde-
Autor(es): dc.contributorInstituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Dourado-
Autor(es): dc.contributorUniversidade do Estado do Amazonas, Escola Superior de Ciências da Saúde-
Autor(es): dc.contributorFundação de Vigilância em Saúde Dr Rosemary Costa Pinto–FVS-RCP-
Autor(es): dc.contributorInstituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Dourado-
Autor(es): dc.contributorUniversidade Federal do Amazonas–UFAM, Escola de Enfermagem de Manaus-
Autor(es): dc.contributorInstituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Dourado-
Autor(es): dc.contributorInstituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Dourado-
Autor(es): dc.contributorInstituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Dourado-
Autor(es): dc.contributorInstituto Leônidas & Maria Deane–ILMD, Fundação Oswaldo Cruz-
Autor(es): dc.contributorInstituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Dourado-
Autor(es): dc.contributorUniversidade do Estado do Amazonas, Escola Superior de Ciências da Saúde-
Autor(es): dc.creatorSousa, José Diego Brito-
Autor(es): dc.creatorPeixoto, Henry Maia-
Autor(es): dc.creatorDevine, Angela-
Autor(es): dc.creatorSilva Neto, Alexandre V.-
Autor(es): dc.creatorBalieiro, Patricia C. S.-
Autor(es): dc.creatorSampaio, Vanderson S.-
Autor(es): dc.creatorSilva, Sheila Vitor-
Autor(es): dc.creatorMendes, Maxwell O.-
Autor(es): dc.creatorSouza, Brenda K. A.-
Autor(es): dc.creatorLacerda, Marcus V. G.-
Autor(es): dc.creatorMonteiro, Wuelton M.-
Data de aceite: dc.date.accessioned2024-10-23T15:38:14Z-
Data de disponibilização: dc.date.available2024-10-23T15:38:14Z-
Data de envio: dc.date.issued2023-10-11-
Data de envio: dc.date.issued2023-10-11-
Data de envio: dc.date.issued2022-03-24-
Fonte completa do material: dc.identifierhttp://repositorio2.unb.br/jspui/handle/10482/46664-
Fonte completa do material: dc.identifierhttps://doi.org/10.1371/journal.pntd.0010325-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-0848-1940-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/888072-
Descrição: dc.descriptionBackground As quantitative glucose 6-phosphate dehydrogenase deficiency (G6PDd) screening tools are evaluated in operational studies, questions remain as to whether they are cost-effective. Here, a cost-effectiveness analysis (CEA) was performed to estimate the Incremental Cost-effectiveness Ratio (ICER) of the introduction of quantitative screening test to detect G6PDd among P. vivax carriers in two municipalities in the Brazilian Amazon. Methodology/Principal findings This cost-effectiveness analysis evaluated the use of the Standard G6PD quantitative screening test in vivax malaria treatment units in two municipalities of the Brazilian Amazon. Using the perspective of the Brazilian public health system, the analysis was performed for the outcome ‘PQ-associated hospitalization avoided’, based on a decision tree model. The results indicated that the G6PDd screening strategy compared with the routine strategy was highly cost-effective, with an ICER of US$495 per additional hospitalization avoided, which represented less than 8% of one Brazilian gross domestic product per capita (US$6,822). The uncertainties evaluated in the sensitivity analysis did not significantly affect the ICER identified in the base-case. Conclusions/Significance This cost-effectiveness analysis showed the quantitative G6PD testing was effective in avoiding PQ-associated hospitalizations. The incorporation of G6PD screening is of paramount importance towards P. vivax malaria elimination in the Amazon to promote the safe use of primaquine and tafenoquine.-
Descrição: dc.descriptionFaculdade de Medicina (FMD)-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherPlos-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsCopyright: © 2022 Brito-Sousa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.-
Palavras-chave: dc.subjectPlasmodium vivax-
Palavras-chave: dc.subjectDeficiência de glicose-6-fosfato desidrogenase-
Título: dc.titleReal-life quantitative G6PD screening in Plasmodium vivax patients in the Brazilian Amazon : a cost-effectiveness analysis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

Não existem arquivos associados a este item.