Transcriptional remodeling patterns in murine dendritic cells infected with Paracoccidioides brasiliensis : more is not necessarily better

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSilva, Calliandra Maria de Souza-
Autor(es): dc.creatorHurtado, Fabián Andrés-
Autor(es): dc.creatorTavares, Aldo Henrique Fonseca Pacheco-
Autor(es): dc.creatorOliveira Júnior, Getúlio Pereira de-
Autor(es): dc.creatorRaiol, Tainá-
Autor(es): dc.creatorNishibe, Christiane-
Autor(es): dc.creatorAgustinho, Daniel Paiva-
Autor(es): dc.creatorAlmeida, Nalvo Franco-
Autor(es): dc.creatorWalter, Maria Emília Machado Telles-
Autor(es): dc.creatorNicola, André Moraes-
Autor(es): dc.creatorBocca, Anamélia Lorenzetti-
Autor(es): dc.creatorAlbuquerque, Patrícia-
Data de aceite: dc.date.accessioned2024-10-23T15:35:01Z-
Data de disponibilização: dc.date.available2024-10-23T15:35:01Z-
Data de envio: dc.date.issued2021-05-19-
Data de envio: dc.date.issued2021-05-19-
Data de envio: dc.date.issued2019-
Fonte completa do material: dc.identifierhttps://repositorio.unb.br/handle/10482/40939-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/jof6040311-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-9064-0735-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-0579-3380-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-6940-401X-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-2242-4798-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-5615-1746-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-8656-5835-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-3323-5300-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-8160-7784-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-1403-9363-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/886717-
Descrição: dc.descriptionMost people infected with the fungus Paracoccidioides spp. do not get sick, but approximately 5% develop paracoccidioidomycosis. Understanding how host immunity determinants influence disease development could lead to novel preventative or therapeutic strategies; hence, we used two mouse strains that are resistant (A/J) or susceptible (B10.A) to P. brasiliensis to study how dendritic cells (DCs) respond to the infection. RNA sequencing analysis showed that the susceptible strain DCs remodeled their transcriptomes much more intensely than those from the resistant strain, agreeing with a previous model of more intense innate immunity response in the susceptible strain. Contrastingly, these cells also repress genes/processes involved in antigen processing and presentation, such as lysosomal activity and autophagy. After the interaction with P. brasiliensis, both DCs and macrophages from the susceptible mouse reduced the autophagy marker LC3-II recruitment to the fungal phagosome compared to the resistant strain cells, confirming this pathway’s repression. These results suggest that impairment in antigen processing and presentation processes might be partially responsible for the inefficient activation of the adaptive immune response in this model.-
Formato: dc.formatapplication/pdf-
Publicador: dc.publisherMDPI-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsCopyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).-
Palavras-chave: dc.subjectParacoccidioides brasiliensis-
Palavras-chave: dc.subjectCélulas dendríticas-
Palavras-chave: dc.subjectResistência-
Palavras-chave: dc.subjectAutofagia-
Palavras-chave: dc.subjectFungos-
Título: dc.titleTranscriptional remodeling patterns in murine dendritic cells infected with Paracoccidioides brasiliensis : more is not necessarily better-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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