Photodynamic therapy directed to melanoma skin cancer by thermosensitive hydrogel containing Chlorophyll A

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Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Sciences, Department of Genetics and Morphology-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Sciences, Department of Genetics and Morphology-
Autor(es): dc.contributorFederal University of Bahia, Health Sciences Institute, Department of Biotechnology-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Sciences, Cellular Biology Department-
Autor(es): dc.contributorSão Paulo State University, School of Pharmaceutical Sciences, Araraquara-
Autor(es): dc.contributorUniversity of Brasília, Institute of Physics-
Autor(es): dc.contributorUniversity of Brasilia, Faculty of Ceilandia-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Sciences, Department of Genetics and Morphology-
Autor(es): dc.creatorAraújo, Joabe Lima-
Autor(es): dc.creatorSilva, Patrícia Bento da-
Autor(es): dc.creatorSantos, Bruno Fonseca-
Autor(es): dc.creatorBáo, Sônia Nair-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorSouza, Paulo Eduardo Narcizo de-
Autor(es): dc.creatorMuehlmann, Luis Alexandre-
Autor(es): dc.creatorAzevedo, Ricardo Bentes-
Data de aceite: dc.date.accessioned2024-10-23T15:29:48Z-
Data de disponibilização: dc.date.available2024-10-23T15:29:48Z-
Data de envio: dc.date.issued2023-12-11-
Data de envio: dc.date.issued2023-12-11-
Data de envio: dc.date.issued2023-11-28-
Fonte completa do material: dc.identifierhttp://repositorio2.unb.br/jspui/handle/10482/46974-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/ph16121659-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/884569-
Descrição: dc.descriptionMelanoma, a severe form of skin cancer intricately linked to genetic and environmental factors, is predicted to reach 100,000 new cases worldwide by 2040, underscoring the need for effective and safe treatment options. In this study, we assessed the efficacy of a photosensitizer called Chlorophyll A (Chl-A) incorporated into hydrogels (HGs) made of chitosan (CS) and poloxamer 407 (P407) for Photodynamic Therapy (PDT) against the murine melanoma cell line B16-F10. The HG was evaluated through various tests, including rheological studies, SEM, and ATR-FTIR, along with cell viability assays. The CS- and P407-based HGs effectively released Chl-A and possessed the necessary properties for topical application. The photodynamic activity of the HG containing Chl-A was evaluated in vitro, demonstrating high therapeutic potential, with an IC50 of 25.99 µM—an appealing result when compared to studies in the literature reporting an IC50 of 173.8 µM for cisplatin, used as a positive control drug. The developed formulation of CS and P407-based HG, serving as a thermosensitive system for topical applications, successfully controlled the release of Chl-A. In vitro cell studies associated with PDT exhibited potential against the melanoma cell line.-
Descrição: dc.descriptionInstituto de Ciências Biológicas (IB)-
Descrição: dc.descriptionDepartamento de Genética e Morfologia (IB GEM)-
Descrição: dc.descriptionDepartamento de Biologia Celular (IB CEL)-
Descrição: dc.descriptionInstituto de Física (IF)-
Descrição: dc.descriptionFaculdade UnB Ceilândia (FCE)-
Descrição: dc.descriptionColegiado de Bases Biológicas e da Saúde (FCE-BASES)-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherMDPI-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).-
Palavras-chave: dc.subjectTerapia fotodinâmica-
Palavras-chave: dc.subjectMelanoma-
Palavras-chave: dc.subjectPele - câncer-
Palavras-chave: dc.subjectHidrogel-
Título: dc.titlePhotodynamic therapy directed to melanoma skin cancer by thermosensitive hydrogel containing Chlorophyll A-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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