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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | University of Brasilia, Faculty of Medicine, Tropical Medicine Centre, Laboratory of Development of Therapeutic Innovations | - |
Autor(es): dc.contributor | University of Brasilia, Faculty of Health Sciences, Postgraduate Program in Pharmaceutical Sciences | - |
Autor(es): dc.contributor | Federal University of Ceará, Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Specialized Medical Mycology Centre | - |
Autor(es): dc.contributor | AlbaNova University Center, KTH Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Chemistry, Division of Glycoscience | - |
Autor(es): dc.contributor | University of Brasilia, Faculty of Medicine, Postgraduate Program in Tropical Medicine | - |
Autor(es): dc.contributor | Federal University of Ceará, Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Specialized Medical Mycology Centre | - |
Autor(es): dc.contributor | Federal University of Ceará, Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Specialized Medical Mycology Centre | - |
Autor(es): dc.contributor | Federal University of Ceará, Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Specialized Medical Mycology Centre | - |
Autor(es): dc.contributor | University of Brasília. Campus Ceilândia | - |
Autor(es): dc.contributor | Federal University of Ceará, Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Specialized Medical Mycology Centre | - |
Autor(es): dc.contributor | Federal University of Ceará, Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Specialized Medical Mycology Centre | - |
Autor(es): dc.contributor | Federal University of Ceará, Department of Physiology and Pharmacology, Laboratory of Natural Products | - |
Autor(es): dc.contributor | AlbaNova University Center, KTH Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Chemistry, Division of Glycoscience | - |
Autor(es): dc.contributor | University of Brasilia, Faculty of Medicine, Tropical Medicine Centre, Laboratory of Development of Therapeutic Innovations | - |
Autor(es): dc.contributor | University of Brasilia, Faculty of Health Sciences, Postgraduate Program in Pharmaceutical Sciences | - |
Autor(es): dc.contributor | University of Brasilia, Faculty of Medicine, Postgraduate Program in Tropical Medicine | - |
Autor(es): dc.contributor | Federal University of Ceará, Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Specialized Medical Mycology Centre | - |
Autor(es): dc.creator | Oliveira, Andressa Souza de | - |
Autor(es): dc.creator | Oliveira, Jonathas Sales de | - |
Autor(es): dc.creator | Kumar, Rajender | - |
Autor(es): dc.creator | Silva, Fabiana Brandão Alves | - |
Autor(es): dc.creator | Fernandes, Mirele Rodrigues | - |
Autor(es): dc.creator | Nobre, Feynman Dias | - |
Autor(es): dc.creator | Costa, Anderson da Cunha | - |
Autor(es): dc.creator | Albuquerque, Patrícia | - |
Autor(es): dc.creator | Sidrim, José Júlio Costa | - |
Autor(es): dc.creator | Rocha, Marcos Fábio Gadelha | - |
Autor(es): dc.creator | Santos, Flavia Almeida | - |
Autor(es): dc.creator | Srivastava, Vaibhav | - |
Autor(es): dc.creator | Romeiro, Luiz Antonio Soares | - |
Autor(es): dc.creator | Brilhante, Raimunda Sâmia Nogueira | - |
Data de aceite: dc.date.accessioned | 2024-10-23T15:25:42Z | - |
Data de disponibilização: dc.date.available | 2024-10-23T15:25:42Z | - |
Data de envio: dc.date.issued | 2024-05-28 | - |
Data de envio: dc.date.issued | 2024-05-28 | - |
Data de envio: dc.date.issued | 2023-08-08 | - |
Fonte completa do material: dc.identifier | http://repositorio2.unb.br/jspui/handle/10482/48134 | - |
Fonte completa do material: dc.identifier | https://doi.org/10.1093/mmy/myad073 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/882787 | - |
Descrição: dc.description | The limited therapeutic options for fungal infections and the increased incidence of fungal strains resistant to antifungal drugs, especially Candida spp., require the development of new antifungal drugs and strategies. Histone deacetylase inhibitors (HDACi), like vorinostat, have been studied in cancer treatment and have antifungal effects, acting alone or synergistically with classical antifungals. Here we investigated the antifungal activity of two novel sustainable HDACi (LDT compounds) based on vorinostat structure. Molecular docking simulation studies reveal that LDT compounds can bind to Class-I HDACs of Candida albicans, C. tropicalis, and Cryptococcus neoformans, which showed similar binding mode to vorinostat. LDT compounds showed moderate activity when tested alone against fungi but act synergistically with antifungal azoles against Candida spp. They reduced biofilm formation by more than 50% in C. albicans (4 μg/mL), with the main action in fungal filamentation. Cytotoxicity of the LDT compounds against RAW264.7 cells was evaluated and LDT536 demonstrated cytotoxicity only at the concentration of 200 μmol/L, while LDT537 showed IC50 values of 29.12 μmol/L. Our data indicated that these sustainable and inexpensive HDACi have potential antifungal and antibiofilm activities, with better results than vorinostat, although further studies are necessary to better understand the mechanism against fungal cells. | - |
Descrição: dc.description | Faculdade de Medicina (FM) | - |
Descrição: dc.description | Faculdade de Ciências da Saúde (FS) | - |
Descrição: dc.description | Departamento de Farmácia (FS FAR) | - |
Descrição: dc.description | Programa de Pós-Graduação em Ciências Farmacêuticas | - |
Descrição: dc.description | Programa de Pós-Graduação em Medicina Tropical | - |
Idioma: dc.language | en | - |
Publicador: dc.publisher | Oxford University Press on behalf of The International Society for Human and Animal Mycology | - |
Relação: dc.relation | https://academic.oup.com/mmy/article/61/8/myad073/7239295 | - |
Direitos: dc.rights | Acesso Restrito | - |
Palavras-chave: dc.subject | Antifúngicos | - |
Palavras-chave: dc.subject | Inibidores de histonas desacetilases | - |
Palavras-chave: dc.subject | Ácido hidroxâmico | - |
Palavras-chave: dc.subject | Biofilme | - |
Título: dc.title | Antifungal activity of sustainable histone deacetylase inhibitors against planktonic cells and biofilms of Candida spp. and Cryptococcus neoformans | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional – UNB |
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