Serum levels of matrix metalloproteinase-1 in Brazilian patients with benign prostatic hyperplasia or prostate cancer

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Autor(es): dc.contributorUniversidade de Brasília-
Autor(es): dc.contributorUniversidade Católica de Brasília-
Autor(es): dc.contributorUniversidade de Brasília-
Autor(es): dc.contributorUniversidade de Brasília-
Autor(es): dc.contributorUniversidade de Brasília-
Autor(es): dc.contributorUniversidade de Brasília-
Autor(es): dc.contributorUniversidade de Brasília-
Autor(es): dc.contributorUniversidade Católica de Brasília-
Autor(es): dc.contributorUniversidade de Brasília-
Autor(es): dc.creatorEl-Chaer, William Khalil-
Autor(es): dc.creatorTonet-Furioso, Audrey Cecília-
Autor(es): dc.creatorMorais Junior, Gilberto Santos-
Autor(es): dc.creatorSouza, Vinícius Carolino de-
Autor(es): dc.creatorAvelar, Gleiciane Gontijo-
Autor(es): dc.creatorHenriques, Adriane Dallanora-
Autor(es): dc.creatorMoraes, Clayton Franco-
Autor(es): dc.creatorNóbrega, Otávio de Tolêdo-
Data de aceite: dc.date.accessioned2024-10-23T15:23:36Z-
Data de disponibilização: dc.date.available2024-10-23T15:23:36Z-
Data de envio: dc.date.issued2024-01-21-
Data de envio: dc.date.issued2024-01-21-
Data de envio: dc.date.issued2020-05-05-
Fonte completa do material: dc.identifierhttp://repositorio2.unb.br/jspui/handle/10482/47427-
Fonte completa do material: dc.identifierhttps://doi.org/10.1155/2020/6012102-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-1511-0387-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-1775-7176-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/881913-
Descrição: dc.descriptionMetalloproteinases (MMPs) are involved in metastatic tumor processes, with changes in circulating levels detected in several cancer types. Here, we compare serum concentrations of metalloproteinase-1 (MMP-1) across individuals clinically diagnosed with prostate cancer (PCa) or benign prostatic hyperplasia (BPH), correcting results for the rs495366 single nucleotide polymorphism (SNP) that predisposes to differential MMP-1 levels. 196 men aged ≥50 years were followed at a university hospital urology outpatient clinic, with clinical, anthropometric, and rectal examinations performed by one urologist. Blood samples obtained prior to any clinical intervention provided baseline MMP-1 and total/free PSA levels as well as metabolic, hormonal, and inflammatory markers. +e SNP was genotyped by real-time PCR. Participants with medical and/or laboratory profile compatible with malignancy composed the PCa group when confirmed by the Gleason scale. As expected, A-allele homozygotes showed reduced levels of MMP-1. Genotype-adjusted analyses revealed the mean MMP-1 level as 2-fold higher in PCa carriers compared to BPH patients. No other differences were found according to the prostatic condition or genotypic distribution, except for the expected raise in total and free PSA levels in PCa. In conclusion, increased serum levels of MMP-1 were observed in this context of prostatic malignancy compared to a benign phenotype, regardless of a genetic influence.-
Descrição: dc.descriptionFaculdade UnB Ceilândia (FCE)-
Descrição: dc.descriptionFaculdade de Ciências da Saúde (FS)-
Descrição: dc.descriptionFaculdade de Medicina (FM)-
Descrição: dc.descriptionPrograma de Pós-Graduação em Ciências da Saúde-
Descrição: dc.descriptionPrograma de Pós-Graduação em Ciências Médicas-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherHindawi-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsCopyright © 2020 William Khalil El-Chaer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.-
Palavras-chave: dc.subjectPróstata - câncer-
Palavras-chave: dc.subjectPróstata - doenças-
Palavras-chave: dc.subjectHiperplasia-
Título: dc.titleSerum levels of matrix metalloproteinase-1 in Brazilian patients with benign prostatic hyperplasia or prostate cancer-
Tipo de arquivo: dc.typelivro digital-
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