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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Sousa, Isabel Garcia | - |
Autor(es): dc.creator | Almo, Manuela Maragno do | - |
Autor(es): dc.creator | Simi, Kelly Cristina Rodrigues | - |
Autor(es): dc.creator | Bezerra, Maryani Andressa Gomes | - |
Autor(es): dc.creator | Andrade, Rosângela Vieira | - |
Autor(es): dc.creator | Maranhão, Andréa Queiroz | - |
Autor(es): dc.creator | Brígido, Marcelo de Macedo | - |
Data de aceite: dc.date.accessioned | 2024-10-23T15:22:59Z | - |
Data de disponibilização: dc.date.available | 2024-10-23T15:22:59Z | - |
Data de envio: dc.date.issued | 2017-07-25 | - |
Data de envio: dc.date.issued | 2017-07-25 | - |
Data de envio: dc.date.issued | 2017-03-14 | - |
Fonte completa do material: dc.identifier | http://repositorio.unb.br/handle/10482/23881 | - |
Fonte completa do material: dc.identifier | https://dx.doi.org/10.1186/s13104-017-2442-y | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/881659 | - |
Descrição: dc.description | Background: Anti-CD3 therapy can induce immunosuppression by several non mutually exclusive mechanisms that have been proposed to explain the therapeutic effect the administration anti-CD3 mAb, but its immunoregulatory mechanism is still not completely clear. In T cells, microRNAs (miRNAs) regulate several pathways, including those associated with immune tolerance. Here, we report changes in miRNA expression in T cells following treatment with anti-human CD3 antibodies. Peripheral blood mononuclear cells were cultured in the presence of the monoclonal antibody OKT3 or a recombinant fragment of humanized anti-CD3. Following these treatments, the expression profiles of 31 miRNA species were assessed in T cells using TaqMan arrays. Results: Eight of the tested miRNAs (miR-155, miR-21, miR-146a, miR-210, miR-17, miR-590-5p, miR-106b and miR- 301a) were statistically significantly up- or down-regulated relative to untreated cells. Conclusions: Stimulation of T cells with anti-human CD3 antibodies alters miRNA expression patterns, including of miRNA species associated with immune regulatory pathways. | - |
Formato: dc.format | application/pdf | - |
Publicador: dc.publisher | BioMed Central | - |
Direitos: dc.rights | Acesso Aberto | - |
Direitos: dc.rights | © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | - |
Palavras-chave: dc.subject | Anticorpos | - |
Palavras-chave: dc.subject | Imunologia | - |
Título: dc.title | MicroRNA expression profiles in human CD3+ T cells following stimulation with anti‑human CD3 antibodies | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional – UNB |
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