The role of T cell subsets and cytokines in the regulation of intracellular bacterial infection

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorOliveira, S. C.-
Autor(es): dc.creatorHarms, J. S.-
Autor(es): dc.creatorRech, E. L.-
Autor(es): dc.creatorRodarte, Renato Santos-
Autor(es): dc.creatorBocca, Anamélia Lorenzetti-
Autor(es): dc.creatorGoes, A. M.-
Autor(es): dc.creatorSplitter, G. A.-
Data de aceite: dc.date.accessioned2024-10-23T15:21:02Z-
Data de disponibilização: dc.date.available2024-10-23T15:21:02Z-
Data de envio: dc.date.issued2017-08-23-
Data de envio: dc.date.issued2017-08-23-
Data de envio: dc.date.issued1998-01-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/24248-
Fonte completa do material: dc.identifierhttps://dx.doi.org/10.1590/S0100-879X1998000100010-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/880830-
Descrição: dc.descriptionCellular immune responses are a critical part of the host's defense against intracellular bacterial infections. Immunity to Brucella abortus crucially depends on antigen-specific T cell-mediated activation of macrophages, which are the major effectors of cell-mediated killing of this organism. T lymphocytes that proliferate in response to B. abortus were characterized for phenotype and cytokine activity. Human, murine, and bovine T lymphocytes exhibited a type 1 cytokine profile, suggesting an analogous immune response in these different hosts. In vivo protection afforded by a particular cell type is dependent on the antigen presented and the mechanism of antigen presentation. Studies using MHC class I and class II knockout mice infected with B. abortus have demonstrated that protective immunity to brucellosis is especially dependent on CD8+ T cells. To target MHC class I presentation we transfected ex vivo a murine macrophage cell line with B. abortus genes and adoptively transferred them to BALB/c mice. These transgenic macrophage clones induced partial protection in mice against experimental brucellosis. Knowing the cells required for protection, vaccines can be designed to activate the protective T cell subset. Lastly, as a new strategy for priming a specific class I-restricted T cell response in vivo, we used genetic immunization by particle bombardment-mediated gene transfer.-
Formato: dc.formatapplication/pdf-
Publicador: dc.publisherAssociação Brasileira de Divulgação Científica-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsBrazilian Journal of Medical and Biological Research - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (Attribution 4.0 International (CC BY 4.0)). Fonte: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100010>. Acesso em: 10 jul 2017.-
Palavras-chave: dc.subjectImunologia veterinária-
Palavras-chave: dc.subjectBacterioses-
Palavras-chave: dc.subjectBrucelose-
Palavras-chave: dc.subjectCitocinas-
Título: dc.titleThe role of T cell subsets and cytokines in the regulation of intracellular bacterial infection-
Tipo de arquivo: dc.typelivro digital-
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