Association between the -174 G/C promoter polymorphism of the interleukin-6 gene and cardiovascular disease risk factors in Brazilian older women

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Autor(es): dc.creatorNóbrega, Otávio de Tolêdo-
Autor(es): dc.creatorFurioso, Audrey Cecília Tonet-
Autor(es): dc.creatorMoraes, Clayton Franco-
Autor(es): dc.creatorGomes, Lucy-
Autor(es): dc.creatorKarnikowski, Margô Gomes de Oliveira-
Autor(es): dc.creatorCórdova, Claudio Olavo de Almeida-
Autor(es): dc.creatorKarnikowski, Mauro-
Data de aceite: dc.date.accessioned2024-10-23T15:18:28Z-
Data de disponibilização: dc.date.available2024-10-23T15:18:28Z-
Data de envio: dc.date.issued2012-12-18-
Data de envio: dc.date.issued2012-12-18-
Data de envio: dc.date.issued2008-01-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/11827-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2006005000190-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/879779-
Descrição: dc.descriptionIn worldwide studies, interleukin-6 (IL-6) is implicated in age-related disturbances. The aim of the present report was to determine the possible association of IL-6 -174 C/G promoter polymorphism with the cytokine profile as well as with the presence of selected cardiovascular risk features. This was a cross-sectional study on Brazilian women aged 60 years or older. A sample of 193 subjects was investigated for impaired glucose regulation, diabetes, hypertension, and dyslipidemia. Genotyping was done by direct sequencing of PCR products. IL-6 and C-reactive protein were quantified by high-sensitivity assays. General linear regression models or the Student t-test were used to compare continuous variables among genotypes, followed by adjustments for confounding variables. The chi-square test was used to compare categorical variables. The genotypes were consistent with Hardy-Weinberg equilibrium proportions. In a recessive model, mean waist-to-hip ratio, serum glycated hemoglobin and serum glucose were markedly lower in C homozygotes (P = 0.001, 0.028, and 0.047, respectively). In a dominant hypothesis, G homozygotes displayed a trend towards higher levels of circulating IL-6 (P = 0.092). Non-parametric analysis revealed that impaired fasting glucose and hypertension were findings approximately 2-fold more frequent among G homozygous subjects (P = 0.042 and 0.043, respectively). Taken together, our results show that the IL-6 -174 G-allele is implicated in a greater cardiovascular risk. To our knowledge, this is the first investigation of IL-6 promoter variants and age-related disturbances in the Brazilian elderly population.-
Descrição: dc.descriptionFaculdade UnB Ceilândia (FCE)-
Descrição: dc.descriptionCurso de Saúde Coletiva (FCE-SC)-
Formato: dc.formatapplication/pdf-
Publicador: dc.publisherAssociação Brasileira de Divulgação Científica-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsBrazilian Journal of Medical and Biological Research - Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons (Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)). Fonte: http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-879X&lng=pt&nrm=iso. Acesso em: 27nov. 2012.-
Palavras-chave: dc.subjectSistema cardiovascular - doenças-
Palavras-chave: dc.subjectCoração - doenças-
Palavras-chave: dc.subjectIdosos - cuidados médicos-
Palavras-chave: dc.subjectGenética humana-
Título: dc.titleAssociation between the -174 G/C promoter polymorphism of the interleukin-6 gene and cardiovascular disease risk factors in Brazilian older women-
Tipo de arquivo: dc.typelivro digital-
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