Antitumor evaluation of amaryllidaceae alkaloids on cancer cell lines : a literature review

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Brasília, Faculty of Health Sciences, Laboratory of Natural Products-
Autor(es): dc.contributorUniversity of Gurupi, Paraíso do Tocantins-
Autor(es): dc.contributorFederal University of Tocantins, Laboratory of Basic and Health Sciences-
Autor(es): dc.contributorUniversity of Brasília, Faculty of Health Sciences, Laboratory of Natural Products-
Autor(es): dc.contributorUniversity of Gurupi, Paraíso do Tocantins-
Autor(es): dc.contributorUniversity of Gurupi, Paraíso do Tocantins-
Autor(es): dc.contributorFaculdade de Palmas-
Autor(es): dc.contributorFederal University of Tocantins, Laboratory of Basic and Health Sciences-
Autor(es): dc.contributorUniversity of Brasília, Faculty of Health Sciences, Laboratory of Natural Products-
Autor(es): dc.creatorPaiva, Maykon Jhuly Martins de-
Autor(es): dc.creatorNascimento, Guilherme Nobre L do-
Autor(es): dc.creatorDamasceno, Iangla Araújo de Melo-
Autor(es): dc.creatorCunha, Lucas Nordhoff Barcelos-
Autor(es): dc.creatorPimentel, Jeremias Emanoel de Sousa-
Autor(es): dc.creatorSilva, Leda Terezinha Freitas e-
Autor(es): dc.creatorCastro, Tayslane Dias-
Autor(es): dc.creatorSilveira, Dâmaris-
Data de aceite: dc.date.accessioned2024-10-23T15:06:04Z-
Data de disponibilização: dc.date.available2024-10-23T15:06:04Z-
Data de envio: dc.date.issued2024-06-07-
Data de envio: dc.date.issued2024-06-07-
Data de envio: dc.date.issued2023-
Fonte completa do material: dc.identifierhttp://repositorio2.unb.br/jspui/handle/10482/48173-
Fonte completa do material: dc.identifierhttps://doi.org/10.29333/ejgm/14040-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-6228-4550-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-4185-0872-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-1281-8566-
Fonte completa do material: dc.identifierhttps://orcid.org/0009-0003-5826-6864-
Fonte completa do material: dc.identifierhttps://orcid.org/0009-0004-2163-1028-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-1909-1286-
Fonte completa do material: dc.identifierhttps://orcid.org/0009-0002-3751-7081-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-1851-5224-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/874305-
Descrição: dc.descriptionAmaryllidaceae alkaloids have attracted significant attention in cancer research for their potential antitumor properties. To date, numerous studies have investigated the effects of these alkaloids on cancer cell lines, but a comprehensive synthesis of the existing evidence through a literature review is warranted. This article presents a comprehensive literature review aimed at evaluating the antitumor effects of amaryllidaceae alkaloids on various cancer cell lines and elucidating the underlying mechanisms of action. A search was conducted in major scientific databases, including Google Scholar, PubMed, Scopus, and Web of Science, to identify relevant studies published between 2013 and 2023. Studies that examined the antitumor effects of amaryllidaceae alkaloids on cancer cell lines were included in the review. Data were extracted, analyzed, and synthesized to provide an in-depth overview of the findings. The alkaloids exhibited potent cytotoxicity and suppressed cell proliferation in a concentration dependent manner. Mechanistic investigations unveiled that amaryllidaceae alkaloids induced apoptosis, cell cycle arrest, and hindered angiogenesis in cancer cells. Moreover, they demonstrated favorable selectivity towards cancer cells, sparing normal cells, suggesting potential as targeted therapies. This literature review consolidates and critically appraises the available evidence on the antitumor effects of amaryllidaceae alkaloids on cancer cell lines. The findings underscore their potential as promising candidates for further exploration in cancer therapeutics. Future preclinical and clinical studies are vital to advance their development and translation into effective anticancer drugs.-
Descrição: dc.descriptionFaculdade de Ciências da Saúde (FS)-
Descrição: dc.descriptionDepartamento de Farmácia (FS FAR)-
Descrição: dc.descriptionPrograma de Pós-Graduação em Ciências Farmacêuticas-
Formato: dc.formatapplication/pdf-
Idioma: dc.languagept_BR-
Publicador: dc.publisherModestum-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rights© 2024 by Author/s and Licensed by Modestum. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.-
Palavras-chave: dc.subjectAmaryllidaceae-
Palavras-chave: dc.subjectAlcalóides-
Palavras-chave: dc.subjectAtividade antitumoral-
Palavras-chave: dc.subjectApoptose-
Palavras-chave: dc.subjectAngiogênese-
Título: dc.titleAntitumor evaluation of amaryllidaceae alkaloids on cancer cell lines : a literature review-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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