Plants from Brazilian cerrado with potent tyrosinase inhibitory activity

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSouza, Paula Monteiro-
Autor(es): dc.creatorElias, Silvia Taveira-
Autor(es): dc.creatorSimeoni, Luiz Alberto-
Autor(es): dc.creatorPaula, José Elias de-
Autor(es): dc.creatorGomes, Sueli Maria-
Autor(es): dc.creatorGuerra, Eliete Neves Silva-
Autor(es): dc.creatorFonseca, Yris Maria-
Autor(es): dc.creatorSilva, Elton Clementino da-
Autor(es): dc.creatorSilveira, Dâmaris-
Autor(es): dc.creatorBatista, Pérola de Oliveira Magalhães Dias-
Data de aceite: dc.date.accessioned2024-10-23T15:05:46Z-
Data de disponibilização: dc.date.available2024-10-23T15:05:46Z-
Data de envio: dc.date.issued2013-06-11-
Data de envio: dc.date.issued2013-06-11-
Data de envio: dc.date.issued2012-11-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/13291-
Fonte completa do material: dc.identifierhttps://dx.doi.org/10.1371/journal.pone.0048589-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/874172-
Descrição: dc.descriptionThe increased amount of melanin leads to skin disorders such as age spots, freckles, melasma and malignant melanoma. Tyrosinase is known to be the key enzyme in melanin production. Plants and their extracts are inexpensive and rich resources of active compounds that can be utilized to inhibit tyrosinase as well as can be used for the treatment of dermatological disorders associated with melanin hyperpigmentation. Using in vitro tyrosinase inhibitory activity assay, extracts from 13 plant species from Brazilian Cerrado were evaluated. The results showed that Pouteria torta and Eugenia dysenterica extracts presented potent in vitro tyrosinase inhibition compared to positive control kojic acid. Ethanol extract of Eugenia dysenterica leaves showed significant (p<0.05) tyrosinase inhibitory activity exhibiting the IC50 value of 11.88 µg/mL, compared to kojic acid (IC50 value of 13.14 µg/mL). Pouteria torta aqueous extract leaves also showed significant inhibitory activity with IC50 value of 30.01 µg/mL. These results indicate that Pouteria torta and Eugenia dysenterica extracts and their isolated constituents are promising agents for skin-whitening or antimelanogenesis formulations.-
Formato: dc.formatapplication/pdf-
Publicador: dc.publisherPLOS-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsPlos One - Copyright: 2012 Souza et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Fonte: http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0048589&representation=PDF. Acesso em: 4 jun. 2013.-
Palavras-chave: dc.subjectPlantas - Cerrados-
Palavras-chave: dc.subjectCerrados - Brasil-
Palavras-chave: dc.subjectMelanina-
Título: dc.titlePlants from Brazilian cerrado with potent tyrosinase inhibitory activity-
Tipo de arquivo: dc.typelivro digital-
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