Potential neuroprotective and antiinfammatory efects provided by omega-3 (DHA) against Zika virus infection in human SH-SY5Y cells

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Autor(es): dc.creatorMelo, Heloísa Antoniella Braz de-
Autor(es): dc.creatorNascimento, Gabriel Pasquarelli do-
Autor(es): dc.creatorCorrêa, Rafael-
Autor(es): dc.creatorAlmeida, Raquel das Neves-
Autor(es): dc.creatorSantos, Igor de Oliveira-
Autor(es): dc.creatorPrado, Paulo Sousa-
Autor(es): dc.creatorPicolo, Victor-
Autor(es): dc.creatorBem, Andreza Fabro de-
Autor(es): dc.creatorPizato, Nathalia Marcolini Pelucio-
Autor(es): dc.creatorMagalhães, Kelly Grace-
Data de aceite: dc.date.accessioned2024-10-23T15:03:03Z-
Data de disponibilização: dc.date.available2024-10-23T15:03:03Z-
Data de envio: dc.date.issued2020-11-10-
Data de envio: dc.date.issued2020-11-10-
Data de envio: dc.date.issued2019-12-26-
Fonte completa do material: dc.identifierhttps://repositorio.unb.br/handle/10482/39623-
Fonte completa do material: dc.identifierhttps://doi.org/10.1038/s41598-019-56556-y-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/872999-
Descrição: dc.descriptionZika virus (ZIKV) has a strong tropism for the nervous system and has been related to post-infection neurological syndromes. Once neuronal cells are infected, the virus is capable of modulating cell metabolism, leading to neurotoxicity and cellular death. The negative efect of ZIKV in neuron cells has been characterized. However, the description of molecules capable of reversing these cytotoxic efects is still under investigation. In this context, it has been largely demonstrated that docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, is highly neuroprotective. Here, we hypothesized that DHA’s neuroprotective proprieties could have an infuence on ZIKV-induced neurotoxicity in SHSY5Y cells. Our data showed that pre-treatment of SH-SY5Y cells with DHA increased the cell viability and proliferation in ZIKV-infected cells. Moreover, DHA triggered an anti-infammatory response in those infected cells. Besides, DHA was capable of restoring mitochondria function and number in ZIKVinfected SH-SY5Y cells. In addition, cells pre-treated with DHA prior to ZIKV infection presented a lower viral load at diferent times of infection. Taking together, these results demonstrated that DHA has a potential anti-infammatory and neuroprotective efect against ZIKV infection in these neuron-like cells and could be a useful tool in the treatment against this virus.-
Formato: dc.formatapplication/pdf-
Publicador: dc.publisherNature Research-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rights(CC BY) - Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2019-
Palavras-chave: dc.subjectÔmega 3-
Palavras-chave: dc.subjectZika vírus-
Título: dc.titlePotential neuroprotective and antiinfammatory efects provided by omega-3 (DHA) against Zika virus infection in human SH-SY5Y cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional – UNB

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