Sex differences in blood pressure regulation during ischemic isometric exercise : the role of the β-adrenergic receptors

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSamora, Milena-
Autor(es): dc.creatorIncognito, Anthony V.-
Autor(es): dc.creatorVianna, Lauro Casqueiro-
Data de aceite: dc.date.accessioned2024-07-24T13:32:53Z-
Data de disponibilização: dc.date.available2024-07-24T13:32:53Z-
Data de envio: dc.date.issued2020-06-09-
Data de envio: dc.date.issued2020-06-09-
Data de envio: dc.date.issued2019-08-10-
Fonte completa do material: dc.identifierhttps://repositorio.unb.br/handle/10482/38005-
Fonte completa do material: dc.identifierhttps://doi.org/10.1152/japplphysiol.00270.2019-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/853777-
Descrição: dc.descriptionWe sought to investigate whether the β-adrenergic receptors play a pivotal role in sex-related differences in arterial blood pressure (BP) regulation during isometric exercise. Sixteen volunteers (8 women) performed 2 min of ischemic isometric handgrip exercise (IHE) and 2 min of postexercise circulatory occlusion (PECO). Heart rate (HR) and beat-to-beat arterial BP were continuously measured. Beat-to-beat estimates of stroke volume (ModelFlow) were obtained and matched with HR to calculate cardiac output (Q̇) and total peripheral resistance (TPR). Two trials were randomly conducted between placebo and nonselective β-adrenergic blockade (40 mg propranolol). Under the placebo condition, the magnitude of the BP response in IHE was lower in women compared with men. During PECO, the BP remained elevated and the sex differences persisted. The β-blockade attenuated the BP response during IHE in men (∆57 ± 4 vs. ∆45 ± 7 mmHg, P = 0.025) due to a reduction in Q̇ (∆3.7 ± 0.5 vs. ∆1.8 ± 0.2 L/min, P = 0.012) while TPR was not affected. In women, however, the BP response during IHE was unchanged (∆27 ± 3 vs. ∆28 ± 3 mmHg, P = 0.889), despite attenuated Q̇ (∆2.7 ± 0.4 vs. ∆1.3 ± 0.2 L/min, P = 0.012). These responses were mediated by a robust increase in TPR under β-blockade (∆−0.2 ± 0.4 vs. ∆2.2 ± 0.7 mmHg·L−1·min, P = 0.012). These findings demonstrate that the sex differences in arterial BP regulation during ischemic IHE are mediated by β-adrenergic receptors.-
Descrição: dc.descriptionFaculdade de Educação Física (FEF)-
Publicador: dc.publisherAmerican Physiological Society-
Relação: dc.relationhttps://journals.physiology.org/doi/abs/10.1152/japplphysiol.00270.2019-
Direitos: dc.rightsAcesso Restrito-
Palavras-chave: dc.subjectPressão arterial-
Palavras-chave: dc.subjectExercícios físicos-
Título: dc.titleSex differences in blood pressure regulation during ischemic isometric exercise : the role of the β-adrenergic receptors-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional – UNB (old)

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