The action of JAK/STAT3 and BMP/HJV/SMAD signaling pathways on hepcidin suppression by Tucum-do-Cerrado in a normal and iron-enriched diets

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorArruda, Sandra Fernandes-
Autor(es): dc.creatorRamos, Larissa Valadares-
Autor(es): dc.creatorBarbosa, Júlia Lima de Alencar-
Autor(es): dc.creatorHankins, Natália Aboudib Campos-
Autor(es): dc.creatorRodrigues, Pedro Augusto Matos-
Autor(es): dc.creatorCunha, Marcela de Sá Barreto da-
Data de aceite: dc.date.accessioned2024-07-24T13:30:18Z-
Data de disponibilização: dc.date.available2024-07-24T13:30:18Z-
Data de envio: dc.date.issued2021-11-23-
Data de envio: dc.date.issued2021-11-23-
Data de envio: dc.date.issued2020-05-22-
Fonte completa do material: dc.identifierhttps://repositorio.unb.br/handle/10482/42425-
Fonte completa do material: dc.identifierhttps://doi.org/10.3390/nu12051515-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/852923-
Descrição: dc.descriptionThe Brazilian savanna fruit, tucum-do-cerrado (Bactris setosa Mart.) reduces hepatic hepcidin levels. Therefore, we investigated the effect of tucum-do-cerrado on the TfR/HFE and/or BMP/HJV/SMAD and JAK/STAT pathways, in normal and excess iron conditions. Rats were treated with: control diet (CT); control diet +15% tucum-do-cerrado (Tuc); iron-enriched diet (+Fe); or iron-enriched diet +15% tucum-do-cerrado (Tuc+Fe). Tucum-do-cerrado (Tuc) decreased hepatic Hamp and Hjv mRNA levels but did not alter Bmp6, Smad7, Tfr1, and Hfe mRNA levels; pSMAD1/5/8 and pSTAT3 protein levels; labile iron pool (LIP); and inflammatory biomarkers, compared to the CT group. The iron-enriched diet increased Hamp mRNA levels, as well as pSMAD1/5/8 and pSTAT3 protein levels, while no difference was observed in Hjv, Bmp6, Smad7, Tfr1, and Hfe mRNA levels and LIP compared to the CT group. The association of tucum-do-cerrado with the iron-enriched diet (Tuc+Fe) decreased Hamp, Hjv, Bmp6, and Hfe mRNA levels and pSTAT3 protein content compared to the +Fe group, while increased Hamp and decreased Hfe mRNA levels compared to the Tuc group. Therefore, the inhibition of hepatic hepcidin by tucum-do-cerrado consumption may involve the downregulation of intestinal Dmt1 and hepatic Hjv expression and deacetylation mediated by SIRT1 by a mechanism that is independent of tissue iron content. However, in excess iron conditions, the modulation of hepatic hepcidin expression by tucum-do-cerrado seems to be partially mediated by the inflammatory signaling pathway, as well as involves the chelating activity of tucum-do-cerrado.-
Descrição: dc.descriptionFaculdade de Ciências da Saúde (FS)-
Descrição: dc.descriptionDepartamento de Nutrição (FS NUT)-
Descrição: dc.descriptionInstituto de Física (IF)-
Descrição: dc.descriptionPrograma de Pós-Graduação em Nutrição Humana-
Formato: dc.formatapplication/pdf-
Publicador: dc.publisherMDPI-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rights(CC BY) © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).-
Palavras-chave: dc.subjectTucum-
Palavras-chave: dc.subjectHepcidina-
Palavras-chave: dc.subjectProteínas-
Palavras-chave: dc.subjectFerro-
Título: dc.titleThe action of JAK/STAT3 and BMP/HJV/SMAD signaling pathways on hepcidin suppression by Tucum-do-Cerrado in a normal and iron-enriched diets-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional – UNB (old)

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