Effects of 174 G/C polymorphism in the promoter region of the interleukin-6 gene on plasma IL-6 levels and muscle strength in elderly women

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Autor(es): dc.creatorPereira, D.S.-
Autor(es): dc.creatorGarcia, D.M.-
Autor(es): dc.creatorNarciso, F.M.S.-
Autor(es): dc.creatorSantos, M.L.A.S.-
Autor(es): dc.creatorDias, J.M.D.-
Autor(es): dc.creatorQueiroz, B.Z.-
Autor(es): dc.creatorSouza, E.R.-
Autor(es): dc.creatorNóbrega, O.T.-
Autor(es): dc.creatorPereira, L.S.M.-
Data de aceite: dc.date.accessioned2024-07-24T12:16:52Z-
Data de disponibilização: dc.date.available2024-07-24T12:16:52Z-
Data de envio: dc.date.issued2017-12-07-
Data de envio: dc.date.issued2017-12-07-
Data de envio: dc.date.issued2011-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/28012-
Fonte completa do material: dc.identifierhttps://dx.doi.org/10.1590/S0100-879X2010007500152-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/826389-
Descrição: dc.descriptionWe investigated the effect of -174 G/C single-nucleotide polymorphism in the promoter region of the IL6 gene on plasma IL-6 levels and muscle strength, and the relationship between IL-6 levels and muscle strength in elderly women. The sample consisted of 199 elderly residents (73.0 ± 7.8 years old) from rest homes and the community in Belo Horizonte, MG, Brazil. -174 G/C polymorphism was determined by direct sequencing of the product by PCR, and plasma IL-6 concentrations were measured by ELISA. Muscle strength in the knee joint was evaluated using a Biodex System 3 Pro® isokinetic dynamometer. ANCOVA was used to determine the effect of polymorphism on IL-6 levels and muscle strength, and the Pearson correlation coefficient to assess the relationship between IL-6 levels and muscle strength. -174 G/C polymorphism was associated with the plasma IL-6 levels of elderly women (P < 0.01) since homozygotes for the G allele showed high IL-6 levels (GG 3.85 pg/mL, GC + CC 2.13 pg/mL). There was no association of polymorphism on muscle strength (P > 0.05). No association was found between IL-6 levels and knee extensor muscle (r = 0.087, P = 0.306) or flexor (r = -0.011, P = 0.894) strength. An interaction between -174 G/C polymorphism and housing conditions of the sample of elderly women was identified, with the effect of genotype on IL-6 levels being higher in the institutionalized elderly. These results support the evidence that -174 G/C polymorphism of the IL6 gene associates with individual variability of plasma IL-6 levels in elderly women.-
Descrição: dc.descriptionEm processamento-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherAssociação Brasileira de Divulgação Científica-
Direitos: dc.rightsAcesso Aberto-
Palavras-chave: dc.subjectInterleukin-6-
Palavras-chave: dc.subjectElderly-
Palavras-chave: dc.subjectMuscular strength-
Palavras-chave: dc.subject174 G/C polymorphism-
Título: dc.titleEffects of 174 G/C polymorphism in the promoter region of the interleukin-6 gene on plasma IL-6 levels and muscle strength in elderly women-
Tipo de arquivo: dc.typeArtigo-
Aparece nas coleções:Repositório Institucional – UNB (old)

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