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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Paula, Roberta S. | - |
Autor(es): dc.creator | Souza, Vinícius C. | - |
Autor(es): dc.creator | Machado-Silva, Wilcelly | - |
Autor(es): dc.creator | Almeida, Bruno Ratier S. | - |
Autor(es): dc.creator | Daros, Andersen C. | - |
Autor(es): dc.creator | Gomes, Lucy | - |
Autor(es): dc.creator | Ferreira, Aparecido P. | - |
Autor(es): dc.creator | Brito, Ciro J. | - |
Autor(es): dc.creator | Córdova, Cláudio | - |
Autor(es): dc.creator | Moraes, Clayton F. | - |
Autor(es): dc.creator | Nóbrega, Otávio T. | - |
Data de aceite: dc.date.accessioned | 2024-07-22T13:14:01Z | - |
Data de disponibilização: dc.date.available | 2024-07-22T13:14:01Z | - |
Data de envio: dc.date.issued | 2017-12-07 | - |
Data de envio: dc.date.issued | 2017-12-07 | - |
Data de envio: dc.date.issued | 2016-12 | - |
Fonte completa do material: dc.identifier | http://repositorio.unb.br/handle/10482/30394 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.6061/clinics/2016(12)09 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/820915 | - |
Descrição: dc.description | The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic risk factors and a clinical history of vascular events. METHODS: Clinical, anthropometric, biochemical and nutritional assessments were conducted with 168 older adults, complemented by genotyping (rs9536314 and rs9527025) and the detection of serum Klotho (ELISA). RESULTS: Klotho levels and haplotypes did not associate with most classic risk factors for vascular events, including markers such as C-reactive protein and homocysteine. A positive association was only found between Klotho levels and the previous occurrence of a myocardial infarction by both correlational (p=0.006) and variance analyses (p<0.001), and these associations were independent of the context. CONCLUSION: Our results suggest that serum Klotho is higher in individuals with a clinical history of myocardial infarction but not with a history of coronary artery disease or stroke. None of the Klotho haplotypes were associated with the variables investigated herein. | - |
Formato: dc.format | application/pdf | - |
Idioma: dc.language | en | - |
Publicador: dc.publisher | Faculdade de Medicina / USP | - |
Direitos: dc.rights | Acesso Aberto | - |
Direitos: dc.rights | Clinics - This is an Open Access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322016001200725&lng=en&nrm=iso. Acesso em: 18 dez. 2017. | - |
Palavras-chave: dc.subject | Biomarcadores | - |
Palavras-chave: dc.subject | Idosos | - |
Palavras-chave: dc.subject | Infarto | - |
Título: dc.title | Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults | - |
Aparece nas coleções: | Repositório Institucional – UNB |
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