Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSpósito, Andrei Carvalho-
Autor(es): dc.creatorMansur, A.P.-
Autor(es): dc.creatorMaranhão, R.C.-
Autor(es): dc.creatorRodrigues-Sobrinho, C.R.M.-
Autor(es): dc.creatorCoelho, O.R.-
Autor(es): dc.creatorRamires, José Antonio F.-
Data de aceite: dc.date.accessioned2024-07-22T13:13:37Z-
Data de disponibilização: dc.date.available2024-07-22T13:13:37Z-
Data de envio: dc.date.issued2010-03-26-
Data de envio: dc.date.issued2010-03-26-
Data de envio: dc.date.issued2001-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/4024-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/820763-
Descrição: dc.description6 f.-
Descrição: dc.descriptionEtofibrate is a hybrid drug which combines niacin with clofibrate. After contact with plasma hydrolases, both constituents are gradually released in a controlled-release manner. In this study, we compared the effects of etofibrate and controlled-release niacin on lipid profile and plasma lipoprotein (a) (Lp(a)) levels of patients with triglyceride levels of 200 to 400 mg/dl, total cholesterol above 240 mg/dl and Lp(a) above 40 mg/dl. These patients were randomly assigned to a double-blind 16-week treatment period with etofibrate (500 mg twice daily, N = 14) or niacin (500 mg twice daily, N = 11). In both treatment groups total cholesterol, VLDL cholesterol and triglycerides were equally reduced and high-density lipoprotein cholesterol was increased. Etofibrate, but not niacin, reduced Lp(a) by 26% and low-density lipoprotein (LDL) cholesterol by 23%. The hybrid compound etofibrate produced a more effective reduction in plasma LDL cholesterol and Lp(a) levels than controlled-release niacin in type IIb dyslipidemic subjects.-
Descrição: dc.descriptionFaculdade de Medicina (FMD)-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Direitos: dc.rightsAcesso Aberto-
Palavras-chave: dc.subjectNiacina-
Palavras-chave: dc.subjectLipoproteína-
Palavras-chave: dc.subjectTriglicerídios-
Palavras-chave: dc.subjectColesterol-
Título: dc.titleEtofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects-
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