Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.creator | Oliveira Júnior, Nelson Gomes de | - |
Autor(es): dc.creator | Fernandes, Gabriel da Rocha | - |
Autor(es): dc.creator | Cardoso, Marlon Henrique | - |
Autor(es): dc.creator | Costa, Fabricio Falconi | - |
Autor(es): dc.creator | Cândido, Elizabete de Souza | - |
Autor(es): dc.creator | Garrone Neto, Domingos | - |
Autor(es): dc.creator | Mortari, Márcia Renata | - |
Autor(es): dc.creator | Schwartz, Elisabeth Nogueira Ferroni | - |
Autor(es): dc.creator | Franco, Octávio Luiz | - |
Autor(es): dc.creator | Alencar, Sérgio Amorim de | - |
Data de aceite: dc.date.accessioned | 2024-07-22T13:12:01Z | - |
Data de disponibilização: dc.date.available | 2024-07-22T13:12:01Z | - |
Data de envio: dc.date.issued | 2017-08-17 | - |
Data de envio: dc.date.issued | 2017-08-17 | - |
Data de envio: dc.date.issued | 2016-02-26 | - |
Fonte completa do material: dc.identifier | http://repositorio.unb.br/handle/10482/24150 | - |
Fonte completa do material: dc.identifier | https://dx.doi.org/10.1038/srep21935 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/820170 | - |
Descrição: dc.description | Stingrays commonly cause human envenoming related accidents in populations of the sea, near rivers and lakes. Transcriptomic profiles have been used to elucidate components of animal venom, since they are capable of providing molecular information on the biology of the animal and could have biomedical applications. In this study, we elucidated the transcriptomic profile of the venom glands from two different freshwater stingray species that are endemic to the Paraná-Paraguay basin in Brazil, Potamotrygon amandae and Potamotrygon falkneri. Using RNA-Seq, we identified species-specific transcripts and overlapping proteins in the venom gland of both species. Among the transcripts related with envenoming, high abundance of hyaluronidases was observed in both species. In addition, we built three-dimensional homology models based on several venom transcripts identified. Our study represents a significant improvement in the information about the venoms employed by these two species and their molecular characteristics. Moreover, the information generated by our group helps in a better understanding of the biology of freshwater cartilaginous fishes and offers clues for the development of clinical treatments for stingray envenoming in Brazil and around the world. Finally, our results might have biomedical implications in developing treatments for complex diseases. | - |
Formato: dc.format | application/pdf | - |
Publicador: dc.publisher | Springer Nature | - |
Direitos: dc.rights | Acesso Aberto | - |
Direitos: dc.rights | © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Fonte: <https://www.nature.com/articles/srep21935>. Acesso em: 31 jul. 2017. | - |
Palavras-chave: dc.subject | Arraia (Peixe) - veneno | - |
Palavras-chave: dc.subject | Peixe de água doce - Brasil | - |
Título: dc.title | Venom gland transcriptome analyses of two freshwater stingrays (Myliobatiformes : Potamotrygonidae) from Brazil | - |
Aparece nas coleções: | Repositório Institucional – UNB |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: