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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology | - |
Autor(es): dc.contributor | University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology | - |
Autor(es): dc.contributor | University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology | - |
Autor(es): dc.contributor | niversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology | - |
Autor(es): dc.contributor | niversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology | - |
Autor(es): dc.contributor | niversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology | - |
Autor(es): dc.contributor | niversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology | - |
Autor(es): dc.contributor | University of Brasília,Institute of Biological Sciences, Department of Cellular Biology, Laboratory of Applied Immunology | - |
Autor(es): dc.contributor | University of Brasília,Institute of Biological Sciences, Department of Cellular Biology, Laboratory of Applied Immunology | - |
Autor(es): dc.contributor | University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology | - |
Autor(es): dc.creator | Mayer, Andréia Biolchi | - |
Autor(es): dc.creator | Amaral, Henrique de Oliveira | - |
Autor(es): dc.creator | Oliveira, Danilo Gustavo R. de | - |
Autor(es): dc.creator | Campos, Gabriel Avohay Alves | - |
Autor(es): dc.creator | Ribeiro, Priscilla Galante | - |
Autor(es): dc.creator | Fernandes, Solange Cristina Rego | - |
Autor(es): dc.creator | Souza, Adolfo Carlos Barros de | - |
Autor(es): dc.creator | Castro, Raffael Júnio Araújo de | - |
Autor(es): dc.creator | Bocca, Anamélia Lorenzetti | - |
Autor(es): dc.creator | Mortari, Márcia Renata | - |
Data de aceite: dc.date.accessioned | 2024-07-22T13:11:11Z | - |
Data de disponibilização: dc.date.available | 2024-07-22T13:11:11Z | - |
Data de envio: dc.date.issued | 2024-02-01 | - |
Data de envio: dc.date.issued | 2024-02-01 | - |
Data de envio: dc.date.issued | 2023-10 | - |
Fonte completa do material: dc.identifier | http://repositorio2.unb.br/jspui/handle/10482/47668 | - |
Fonte completa do material: dc.identifier | https://doi.org/10.1016/j.npep.2023.102390 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/819881 | - |
Descrição: dc.description | Venom-derived peptides are important sources for the development of new therapeutic molecules, especially due to their broad pharmacological activity. Previously, our research group identified a novel natural peptide, named fraternine, with promising effects for the treatment of Parkinson's disease. In the present paper, we synthesized three peptides bioinspired in fraternine: fra-10, fra-14, and fra-24. They were tested in the 6-OHDA-induced model of parkinsonism, quantifying motor coordination, levels of TH+ neurons in the substantia nigra pars compacta (SN), and inflammation mediators TNF-α, IL-6, and IL-1ß in the cortex. Peptides fra-14 and fra-10 improved the motor coordination in relation to 6-OHDA lesioned animals. However, most of the peptides were toxic in the doses applied. All three peptides reduced the intensity of the lesion induced rotations in the apomorphine test. Fra-24 higher dose increased the number of TH+ neurons in SN and reduced the concentration of TNF-α in the cortex of 6-OHDA lesioned mice. Overall, only the peptide fra-24 presented a neuroprotection effect on dopaminergic neurons of SN and a reduction of cytokine TNF-α levels, making it worthy of consideration for the treatment of PD. | - |
Descrição: dc.description | Instituto de Ciências Biológicas (IB) | - |
Descrição: dc.description | Departamento de Ciências Fisiológicas (IB CFS) | - |
Descrição: dc.description | Departamento de Biologia Celular (IB CEL) | - |
Idioma: dc.language | en | - |
Publicador: dc.publisher | Elsevier Ltd. | - |
Relação: dc.relation | https://www.sciencedirect.com/science/article/pii/S0143417923000719 | - |
Direitos: dc.rights | Acesso Restrito | - |
Palavras-chave: dc.subject | Parkinson, Doença de - tratamento | - |
Palavras-chave: dc.subject | Peptídeos sintéticos | - |
Palavras-chave: dc.subject | Vespa - veneno | - |
Palavras-chave: dc.subject | Medicamentos | - |
Palavras-chave: dc.subject | Coordenação motora | - |
Título: dc.title | New fraternine analogues : evaluation of the antiparkinsonian effect in the model of Parkinson’s disease | - |
Aparece nas coleções: | Repositório Institucional – UNB |
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