New fraternine analogues : evaluation of the antiparkinsonian effect in the model of Parkinson’s disease

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology-
Autor(es): dc.contributorniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology-
Autor(es): dc.contributorniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology-
Autor(es): dc.contributorniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology-
Autor(es): dc.contributorniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology-
Autor(es): dc.contributorUniversity of Brasília,Institute of Biological Sciences, Department of Cellular Biology, Laboratory of Applied Immunology-
Autor(es): dc.contributorUniversity of Brasília,Institute of Biological Sciences, Department of Cellular Biology, Laboratory of Applied Immunology-
Autor(es): dc.contributorUniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology-
Autor(es): dc.creatorMayer, Andréia Biolchi-
Autor(es): dc.creatorAmaral, Henrique de Oliveira-
Autor(es): dc.creatorOliveira, Danilo Gustavo R. de-
Autor(es): dc.creatorCampos, Gabriel Avohay Alves-
Autor(es): dc.creatorRibeiro, Priscilla Galante-
Autor(es): dc.creatorFernandes, Solange Cristina Rego-
Autor(es): dc.creatorSouza, Adolfo Carlos Barros de-
Autor(es): dc.creatorCastro, Raffael Júnio Araújo de-
Autor(es): dc.creatorBocca, Anamélia Lorenzetti-
Autor(es): dc.creatorMortari, Márcia Renata-
Data de aceite: dc.date.accessioned2024-07-22T13:11:11Z-
Data de disponibilização: dc.date.available2024-07-22T13:11:11Z-
Data de envio: dc.date.issued2024-02-01-
Data de envio: dc.date.issued2024-02-01-
Data de envio: dc.date.issued2023-10-
Fonte completa do material: dc.identifierhttp://repositorio2.unb.br/jspui/handle/10482/47668-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.npep.2023.102390-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/819881-
Descrição: dc.descriptionVenom-derived peptides are important sources for the development of new therapeutic molecules, especially due to their broad pharmacological activity. Previously, our research group identified a novel natural peptide, named fraternine, with promising effects for the treatment of Parkinson's disease. In the present paper, we synthesized three peptides bioinspired in fraternine: fra-10, fra-14, and fra-24. They were tested in the 6-OHDA-induced model of parkinsonism, quantifying motor coordination, levels of TH+ neurons in the substantia nigra pars compacta (SN), and inflammation mediators TNF-α, IL-6, and IL-1ß in the cortex. Peptides fra-14 and fra-10 improved the motor coordination in relation to 6-OHDA lesioned animals. However, most of the peptides were toxic in the doses applied. All three peptides reduced the intensity of the lesion induced rotations in the apomorphine test. Fra-24 higher dose increased the number of TH+ neurons in SN and reduced the concentration of TNF-α in the cortex of 6-OHDA lesioned mice. Overall, only the peptide fra-24 presented a neuroprotection effect on dopaminergic neurons of SN and a reduction of cytokine TNF-α levels, making it worthy of consideration for the treatment of PD.-
Descrição: dc.descriptionInstituto de Ciências Biológicas (IB)-
Descrição: dc.descriptionDepartamento de Ciências Fisiológicas (IB CFS)-
Descrição: dc.descriptionDepartamento de Biologia Celular (IB CEL)-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier Ltd.-
Relação: dc.relationhttps://www.sciencedirect.com/science/article/pii/S0143417923000719-
Direitos: dc.rightsAcesso Restrito-
Palavras-chave: dc.subjectParkinson, Doença de - tratamento-
Palavras-chave: dc.subjectPeptídeos sintéticos-
Palavras-chave: dc.subjectVespa - veneno-
Palavras-chave: dc.subjectMedicamentos-
Palavras-chave: dc.subjectCoordenação motora-
Título: dc.titleNew fraternine analogues : evaluation of the antiparkinsonian effect in the model of Parkinson’s disease-
Aparece nas coleções:Repositório Institucional – UNB

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