Novel sustainable-by-design HDAC inhibitors for the treatment of Alzheimer’s disease

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Brasília, Health Sciences Faculty, Department of Pharmacy-
Autor(es): dc.contributorCatholic University of Brasilia, LADETER-
Autor(es): dc.contributorUniversity of Brasília, Health Sciences Faculty, Department of Pharmacy-
Autor(es): dc.contributorUniversity of Brasília, Health Sciences Faculty, Department of Pharmacy-
Autor(es): dc.contributorUniversity of Brasília, Health Sciences Faculty, Department of Pharmacy-
Autor(es): dc.contributorUniversity of Brasília, Health Sciences Faculty, Department of Pharmacy-
Autor(es): dc.contributorAlma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnology-
Autor(es): dc.contributorScuola Internazionale Superiore di Studi Avanzati (SISSA), Department of Neuroscience, Laboratory of Prion Biology-
Autor(es): dc.contributorUniversity Hospital Hradec Kralove, Biomedical Research Center-
Autor(es): dc.contributorUniversity Hospital Hradec Kralove, Biomedical Research Center-
Autor(es): dc.contributorAlma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnology-
Autor(es): dc.contributorUniversity of Freiburg, Institute of Pharmaceutical Sciences-
Autor(es): dc.contributorUniversity of Freiburg, Institute of Pharmaceutical Sciences-
Autor(es): dc.contributorUniversity of Milan, Department of Pharmaceutical Science-
Autor(es): dc.contributorUniversity of Milan, Department of Pharmaceutical Science-
Autor(es): dc.contributorAlma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnology-
Autor(es): dc.contributorAlma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnology-
Autor(es): dc.contributorAlma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnology-
Autor(es): dc.contributorAlma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnology-
Autor(es): dc.creatorRomeiro, Luiz Antonio Soares-
Autor(es): dc.creatorNunes, Jéssica Larissa da Costa-
Autor(es): dc.creatorMiranda, Camila de Oliveira-
Autor(es): dc.creatorCardoso, Gabriella Simões Heyn Roth-
Autor(es): dc.creatorOliveira, Andressa Souza de-
Autor(es): dc.creatorGandini, Annachiara-
Autor(es): dc.creatorKobrlova, Tereza-
Autor(es): dc.creatorSoukup, Ondrej-
Autor(es): dc.creatorRossi, Michele-
Autor(es): dc.creatorSenger, Johanna-
Autor(es): dc.creatorJung, Manfred-
Autor(es): dc.creatorGervasoni, Silvia-
Autor(es): dc.creatorVistoli, Giulio-
Autor(es): dc.creatorPetralla, Sabrina-
Autor(es): dc.creatorMassenzio, Francesca-
Autor(es): dc.creatorMonti, Barbara-
Autor(es): dc.creatorBolognesi, Maria Laura-
Data de aceite: dc.date.accessioned2024-07-22T13:06:02Z-
Data de disponibilização: dc.date.available2024-07-22T13:06:02Z-
Data de envio: dc.date.issued2024-06-05-
Data de envio: dc.date.issued2024-06-05-
Data de envio: dc.date.issued2019-03-29-
Fonte completa do material: dc.identifierhttp://repositorio2.unb.br/jspui/handle/10482/48163-
Fonte completa do material: dc.identifierhttp://orcid.org/0000-0002-2888-9636-
Fonte completa do material: dc.identifierhttp://orcid.org/0000-0002-6361-7716-
Fonte completa do material: dc.identifierhttp://orcid.org/0000-0002-3939-5172-
Fonte completa do material: dc.identifierhttp://orcid.org/0000-0002-1289-5361-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/817854-
Descrição: dc.descriptionAlzheimer’s disease (AD) represents a global problem, with an estimation of the majority of dementia patients in low- and middle-income countries by 2050. Thus, the development of sustainable drugs has attracted much attention in recent years. In light of this, taking inspiration from the HDAC inhibitor vorinostat (1), we develop the first HDAC inhibitors derived from cashew nut shell liquid (CNSL), an inexpensive agro-food waste material. CNSL derivatives 8 and 9 display a HDAC inhibitory profile similar to 1, together with a more promising safety for 9 compared to 1. Moreover, both compounds and particularly 9 were able to effectively modulate glial cell-induced inflammation and to revert the pro-inflammatory phenotype. All these results demonstrate that the use of inexpensive food waste materials could be successfully applied for the development of accessible and sustainable drug candidates for the treatment of AD.-
Descrição: dc.descriptionFaculdade de Ciências da Saúde (FS)-
Descrição: dc.descriptionDepartamento de Farmácia (FS FAR)-
Idioma: dc.languageen-
Publicador: dc.publisherAmerican Chemical Society-
Relação: dc.relationhttps://pubs.acs.org/doi/10.1021/acsmedchemlett.9b00071-
Direitos: dc.rightsAcesso Restrito-
Palavras-chave: dc.subjectAlzheimer, Doença de-
Palavras-chave: dc.subjectCastanha de caju-
Palavras-chave: dc.subjectMedicamentos-
Palavras-chave: dc.subjectImunomodulação-
Título: dc.titleNovel sustainable-by-design HDAC inhibitors for the treatment of Alzheimer’s disease-
Aparece nas coleções:Repositório Institucional – UNB

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