Health-related quality of life outcomes in head and neck cancer : results from a prospective, real-world data study with Brazilian patients treated with intensity modulated radiation therapy, conformal and conventional radiation techniques

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Autor(es): dc.contributorEORTC Quality of Life Group, Head and Neck Tumors, Brussels, Belgium-
Autor(es): dc.contributorBrasília University, Radiation therapy Department-
Autor(es): dc.contributorBrasília University, Radiation therapy Department-
Autor(es): dc.contributorAC Camargo Cancer Center–São Paulo-
Autor(es): dc.contributorHospital Heliópolis, São Paulo-
Autor(es): dc.contributorPrevent Sênior, São Paulo-
Autor(es): dc.contributorBrasília University, Radiation therapy Department-
Autor(es): dc.contributorPrevent Sênior, São Paulo-
Autor(es): dc.contributorUniversity of Campinas, Oncology Department-
Autor(es): dc.contributorUniversity of Campinas, Oncology Department-
Autor(es): dc.contributorSanta Casa de Bagé-
Autor(es): dc.contributorPontifícia Universidade Católica, Porto Alegre, Radiation therapy Department-
Autor(es): dc.contributorHospital Geral de Caxias do Sul-
Autor(es): dc.contributorOncobeda, Centro Integrado de Oncologia, Campos, RJ-
Autor(es): dc.contributorBrasília University, Radiation therapy Department-
Autor(es): dc.contributorHospital Bruno Born, Lajeado, RS, Brazil-
Autor(es): dc.contributorBrasília University, Radiation therapy Department-
Autor(es): dc.contributorSociété Franco-Brésilienne de Cancérologie, Nice, France-
Autor(es): dc.contributorAC Camargo Cancer Center–São Paulo-
Autor(es): dc.creatorSantos, Marcos-
Autor(es): dc.creatorSilva, Luís Felipe Oliveira e-
Autor(es): dc.creatorKohler, Hugo F.-
Autor(es): dc.creatorCurioni, Otavio-
Autor(es): dc.creatorVilela, Ricardo-
Autor(es): dc.creatorFang, Marcel-
Autor(es): dc.creatorLima, Carmen Silvia Passos-
Autor(es): dc.creatorGomes, João Pedro-
Autor(es): dc.creatorChaves, Aline-
Autor(es): dc.creatorResende, Bruno-
Autor(es): dc.creatorTrindade, Karine-
Autor(es): dc.creatorCollares, Mauricio-
Autor(es): dc.creatorObs, Fernando-
Autor(es): dc.creatorBrollo, Janaina-
Autor(es): dc.creatorCavalieri, Ronaldo-
Autor(es): dc.creatorFerreira, Ediane-
Autor(es): dc.creatorBrust, Leandro-
Autor(es): dc.creatorRamos, Doralina do Amaral Rabello-
Autor(es): dc.creatorDomenge, Christian-
Autor(es): dc.creatorKowalski, Luiz Paulo-
Data de aceite: dc.date.accessioned2024-07-22T12:54:11Z-
Data de disponibilização: dc.date.available2024-07-22T12:54:11Z-
Data de envio: dc.date.issued2023-10-09-
Data de envio: dc.date.issued2023-10-09-
Data de envio: dc.date.issued2020-09-21-
Fonte completa do material: dc.identifierhttp://repositorio2.unb.br/jspui/handle/10482/46640-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.ijrobp.2020.09.044-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/813863-
Descrição: dc.descriptionPurpose: To compare global health-related quality of life (HRQoL) and overall survival (OS) in patients with head and neck cancer treated with intensity modulated radiation therapy (IMRT), conformal radiation therapy (3DCRT) or conventional ra- diation therapy (2DRT). Methods and Materials: In this real-world, multi-institutional and prospective study, HRQoL outcomes were assessed using the European Organisation for Research and Treatment of Cancer Quality-of-life Questionnaire Core 30 (EORTC QLQ-C30) and European Organisation for Research and Treatment of Cancer Quality-of-life Questionnaire Head and Neck 43 (H&N43) questionnaires. Item response theory was used to generate a global HRQoL score, based on the 71 questions from both forms. The effect of treatment modality on HRQoL was studied using multivariate regression analyses. Survival was estimated using the Kaplan-Meyer method, and groups were compared by the log-rank test. Results: Five hundred and seventy patients from 13 institutions were included. Median follow-up was 12.2 months. Concern- ing the radiation technique, 29.5% of the patients were treated with 2DRT, 43.7% received 3DCRT, and 26.8% were treated with IMRT. A higher proportion of patients receiving 2DRT had a treatment interruption of more than 5 days (69% vs 50.2% for 3DCRT and 42.5% for IMRT). IMRT had a statistically significant positive effect on HRQoL compared with 3DCRT (bZ 2.627, standard error Z 0.804, P Z .001) and 2DRT had a statistically significant negative effect compared with 3DCRT (bZ 5.075, standard error Z 0.926, P < .001). Patients receiving 2DRT presented a worse OS (P Z .01). There were no differences in OS when IMRT was compared with 3DCRT. Conclusions: IMRT provided better HRQoL than 3DCRT, which provided better HRQoL than 2DRT. Patients receiving 2DRT presented a worse OS, which might be related to more frequent treatment interruptions. Ó 2020 Elsevier Inc. All rights reserved.-
Idioma: dc.languageen-
Publicador: dc.publisherElvsevier Inc.-
Relação: dc.relationhttps://www.sciencedirect.com/science/article/pii/S0360301620343467?via%3Dihub-
Direitos: dc.rightsAcesso Restrito-
Palavras-chave: dc.subjectQualidade de vida-
Palavras-chave: dc.subjectSaúde-
Palavras-chave: dc.subjectCabeça - câncer-
Palavras-chave: dc.subjectPescoço - câncer-
Palavras-chave: dc.subjectRadioterapia-
Título: dc.titleHealth-related quality of life outcomes in head and neck cancer : results from a prospective, real-world data study with Brazilian patients treated with intensity modulated radiation therapy, conformal and conventional radiation techniques-
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