Melatonin prevents age-related hearing loss in the murin experimental model

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Autor(es): dc.contributormailto:lucienymserra@gmail.com-
Autor(es): dc.contributormailto:andremarjy@uol.com.br-
Autor(es): dc.creatorSerra, Lucieny Silva Martins-
Autor(es): dc.creatorAraújo, Juliana Gusmão de-
Autor(es): dc.creatorNovanta, Gabriela-
Autor(es): dc.creatorLauand, Lucas-
Autor(es): dc.creatorSilva, Eduardo Magalhães da-
Autor(es): dc.creatorKückelhaus, Selma Aparecida Souza-
Autor(es): dc.creatorSampaio, André Luiz Lopes-
Data de aceite: dc.date.accessioned2024-07-22T12:33:37Z-
Data de disponibilização: dc.date.available2024-07-22T12:33:37Z-
Data de envio: dc.date.issued2022-11-21-
Data de envio: dc.date.issued2022-11-21-
Data de envio: dc.date.issued2022-06-14-
Fonte completa do material: dc.identifierhttps://repositorio.unb.br/handle/10482/45209-
Fonte completa do material: dc.identifierhttps://doi.org/10.1016/j.bjorl.2022.06.002-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-8113-7222-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-7853-3016-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0003-4494-3353-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-2777-9494-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-5132-8370-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-7677-772X-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-7611-1303-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/806380-
Descrição: dc.descriptionObjective: The present study aimed to perform a morphological and morphometric analysis of cochlear structures of C57BL/6J mice receiving oral melatonin for a 12-month period. Methods: 32 male C57BL/6J were divided into control and melatonin groups. Control received saline and ethanol solution and melatonin group, 50 L of 10 mg of melatonin/kg/day orally for a 12-month period. After de experiment the animals were sacrificed into a 40% concentration of CO2 chamber, and the blades were morphological and morphometrically analyzed. Results: The melatonin group revealed a higher median density of viable cells (45 ± 10.28 cells/100 m2, 31---73, vs. 32 ± 7.47 cells/100 m2, 25---48). The median area of stria vascularis was 55.0 ± 12.27 cells/100 m2 (38---80) in the control, and 59.0 ± 16.13 cells/100 m2 (40---134) in the melatonin group. The morphometric analysis of the spiral ligament reveals a higher median of total viable neurons in the melatonin (41 ± 7.47 cells/100 m2, 27---60) than in the control group (31 ± 5.68 cells/100 m2, 21---44). Conclusion: Although melatonin is a potent antioxidant, it does not completely neutralize the occurrence of presbycusis; however, it may delay the onset of this condition.-
Descrição: dc.descriptionFaculdade de Medicina (FMD)-
Formato: dc.formatapplication/pdf-
Publicador: dc.publisherElsevier-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rights1808-8694/© 2022 Associacão Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Fonte: https://www.sciencedirect.com/science/article/pii/S1808869422000829?via%3Dihub. Acesso em: 22 nov. 2022.-
Palavras-chave: dc.subjectMelatonina-
Palavras-chave: dc.subjectPerda auditiva-
Palavras-chave: dc.subjectCélulas ciliadas externas-
Título: dc.titleMelatonin prevents age-related hearing loss in the murin experimental model-
Aparece nas coleções:Repositório Institucional – UNB

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