Valorizing constituents of cashew nut shell liquid toward the sustainable development of new drugs against chagas disease

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Brasília, Faculty of Medicine, Tropical Medicine Center-
Autor(es): dc.contributorNational Hellenic Research Foundation, Institute of Chemical Biology-
Autor(es): dc.contributorUniversity of Brasília, Faculty of Health Sciences, Department of Pharmacy-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho-
Autor(es): dc.contributorUniversity of Brasília, Faculty of Health Sciences, Department of Pharmacy-
Autor(es): dc.contributorNational Institute of Metrology, Quality and Technology - Inmetro, Laboratory of Metrology Applied to Life Sciences-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro, Centro Nacional de Biologia Estrutural e Bioimagem, Centro de Ciências da Saúde (CCS)-
Autor(es): dc.contributorNational Hellenic Research Foundation, Institute of Chemical Biology-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho-
Autor(es): dc.contributorAlma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnology-
Autor(es): dc.contributorUniversity of Brasília, Faculty of Medicine, Tropical Medicine Center-
Autor(es): dc.contributorUniversity of Brasília, Faculty of Health Sciences, Department of Pharmacy-
Autor(es): dc.contributorNational Hellenic Research Foundation, Institute of Chemical Biology-
Autor(es): dc.creatorLemes, Laís Flávia Nunes-
Autor(es): dc.creatorMagoulas, George E.-
Autor(es): dc.creatorOliveira, Andressa Souza de-
Autor(es): dc.creatorBarrias, Emile-
Autor(es): dc.creatorNascente, Luciana de Camargo-
Autor(es): dc.creatorGranado, Renato-
Autor(es): dc.creatorSilva, Sara Teixeira de Macedo-
Autor(es): dc.creatorAssimomytis, Nikos-
Autor(es): dc.creatorSouza, Wanderley de-
Autor(es): dc.creatorBolognesi, Maria Laura-
Autor(es): dc.creatorRomeiro, Luiz Antonio Soares-
Autor(es): dc.creatorCalogeropoulou, Theodora-
Data de aceite: dc.date.accessioned2024-07-22T12:16:44Z-
Data de disponibilização: dc.date.available2024-07-22T12:16:44Z-
Data de envio: dc.date.issued2024-06-05-
Data de envio: dc.date.issued2024-06-05-
Data de envio: dc.date.issued2023-06-12-
Fonte completa do material: dc.identifierhttp://repositorio2.unb.br/jspui/handle/10482/48162-
Fonte completa do material: dc.identifierhttps://doi.org/10.1021/acsinfecdis.3c00076-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-1289-5361-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0001-5679-0820-
Fonte completa do material: dc.identifierhttps://orcid.org/0000-0002-3369-5393-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/800160-
Descrição: dc.descriptionSix new ether phospholipid analogues encompassing constituents from cashew nut shell liquid as the lipid portion were synthesized in an effort to valorize byproducts of the cashew industry toward the generation of potent compounds against Chagas disease. Anacardic acids, cardanols, and cardols were used as the lipid portions and choline as the polar headgroup. The compounds were evaluated for their in vitro antiparasitic activity against different developmental stages of Trypanosoma cruzi. Compounds 16 and 17 were found to be the most potent against T. cruzi epimastigotes, trypomastigotes, and intracellular amastigotes exhibiting selectivity indices against the latter 32-fold and 7-fold higher than current drug benznidazole, respectively. Hence, four out of six analogues can be considered as hit-compounds toward the sustainable development of new treatments for Chagas disease, based on inexpensive agro-waste material.-
Descrição: dc.descriptionFaculdade de Medicina (FM)-
Descrição: dc.descriptionFaculdade de Ciências da Saúde (FS)-
Descrição: dc.descriptionDepartamento de Farmácia (FS FAR)-
Idioma: dc.languageen-
Publicador: dc.publisherAmerican Chemical Society-
Relação: dc.relationhttps://pubs.acs.org/doi/10.1021/acsinfecdis.3c00076?ref=PDF-
Direitos: dc.rightsAcesso Restrito-
Palavras-chave: dc.subjectCastanha de caju-
Palavras-chave: dc.subjectAtividade antiparasitária-
Palavras-chave: dc.subjectTrypanosoma cruzi-
Título: dc.titleValorizing constituents of cashew nut shell liquid toward the sustainable development of new drugs against chagas disease-
Aparece nas coleções:Repositório Institucional – UNB

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