Simvastatin and biphasic calcium phosphate affects bone formation in critical-sized rat calvarial defects

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MetadadosDescriçãoIdioma
Autor(es): dc.creatorSantana, Washington Macedo de-
Autor(es): dc.creatorSousa, Dircilei Nascimento de-
Autor(es): dc.creatorFerreira, Vania Maria Moraes-
Autor(es): dc.creatorDuarte, Wagner Rodrigues-
Data de aceite: dc.date.accessioned2024-07-22T12:14:56Z-
Data de disponibilização: dc.date.available2024-07-22T12:14:56Z-
Data de envio: dc.date.issued2017-12-07-
Data de envio: dc.date.issued2017-12-07-
Data de envio: dc.date.issued2016-05-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/30182-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/S0102-865020160050000002-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/799537-
Descrição: dc.descriptionPurpose: to investigate the effects of locally applied simvastatin plus biphasic calcium phosphate (BoneCeramic(r)) or collagen sponge on bone formation in critical-sized bone defects. Methods: thirty defects of 5mm in diameter were created bilaterally with a trephine bur in the calvariae of fifteen Wistar rats. The defects were divided into five groups: group 1 - control, no treatment; group 2 (BoneCeramic(r)); group 3 (BoneCeramic(r) + 0.1mg simvastatin); group 4 (collagen sponge); and group 5 (collagen sponge + 0.1mg simvastatin). After eight weeks the animals were euthanized and their calvariae were histologically processed. Hematoxylin and eosin-stained sections were subjected to histological and histomorphometrical analyses. The area of newly formed bone was calculated and compared between groups. Results: the greater amount of a bone-like tissue was formed around the carrier in group 3 (BoneCeramic(r) + 0.1mg simvastatin) followed by group 2 (BoneCeramic(r)), and almost no bone was formed in the other groups. Group 3 was significantly different compared to group 2, and both groups were significantly different compared to the other groups. Conclusion: simvastatin combined with BoneCeramic(r) induced significantly greater amounts of newly formed bone and has great potential for the healing of bone defects.-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia-
Direitos: dc.rightsAcesso Aberto-
Direitos: dc.rightsActa Cirurgica Brasileira - This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016000500300&lng=en&nrm=iso. Acesso em: 6 mar. 2018.-
Palavras-chave: dc.subjectCálcio-
Palavras-chave: dc.subjectOssos - crescimento-
Palavras-chave: dc.subjectRatos-
Título: dc.titleSimvastatin and biphasic calcium phosphate affects bone formation in critical-sized rat calvarial defects-
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